Pathway Report

Basic Information

Name	regulation of synaptic plasticity
GO Link	ID: GO:0048167 Name: regulation of synaptic plasticity Type: biological process
Description	biological_process. A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.[GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290]
No. of Studies (Positive/Negative)	1 (1/0)

Positive relationship between regulation of synaptic plasticity and MDD (count: 0)

Positive relationships between regulation of synaptic plasticity and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
synaptic and neuritic remodelling		Aldosterone(aldosterone)	molecule	Hlavacova, 2011	animal model		Aldosterone treatment resulted in transcriptional changes of...... Aldosterone treatment resulted in transcriptional changes of genes in the hippocampus involved in synaptic and neuritic remodelling More...

Positive relationship network of regulation of synaptic plasticity in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between regulation of synaptic plasticity and MDD (count: 0)

Negative relationships between regulation of synaptic plasticity and other components at different levels (count: 0)

Pathway regulation of synaptic plasticity related genes in MK4MDD (count: 6)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	Literature-origin; Protein mapped	2(2/0)
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	Literature-origin	1(1/0)
CNTN4	contactin 4	Literature-origin	1(1/0)
PSEN1	presenilin 1	Literature-origin	1(1/0)
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	Literature-origin; Protein mapped	2(2/0)
CALB1	calbindin 1, 28kDa	Literature-origin; Protein mapped	1(1/0)