Brain Morphology and Function Report

Name	anterior insula
Brain Morphology	Please reference to the description for Insula
No. of Studies (Positive/Negative)	5(5/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
contralateral anterior insula	Giesecke, 2005	patients and normal controls		Symptoms of depression and the presence of MDD were associat...... Symptoms of depression and the presence of MDD were associated with the magnitude of pain-evoked neuronal activations in brain regions associated with affective pain processing (the amygdalae and contralateral anterior insula). More...
anterior insula	Remijnse, 2009	patients and normal controls		Imaging results showed MDD-specific hyperactivity in the ant...... Imaging results showed MDD-specific hyperactivity in the anterior insula during punishment processing and in the putamen during reward processing. More...
anterior insula	Wiebking, 2010	patients and normal controls		MDD patients showed significantly higher scores in the BPQ(B...... MDD patients showed significantly higher scores in the BPQ(Body Perception Questionnaire) and reduced neural activity during rest periods, particularly in the bilateral anterior insula. Both BPQ scores and left anterior insula signal changes correlated with depression severity. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
anterior insula		Punishment processing(punishment processing)	cognition and behavior	Remijnse, 2009	patients and normal controls		Imaging results showed MDD-specific hyperactivity in the ant...... Imaging results showed MDD-specific hyperactivity in the anterior insula during punishment processing and in the putamen during reward processing. More...
anterior insula		Depressed mood(depressed mood)	symptoms	Mayberg, 1999	patients and normal controls		With sadness, increases in limbic-paralimbic blood flow were...... With sadness, increases in limbic-paralimbic blood flow were identified. More...
anterior insula		Increased agitation(anxiety/somatization)	symptoms	Brody, 2001	patients only		Improvement in anxiety/somatization [ANX] and tension [TENS]...... Improvement in anxiety/somatization [ANX] and tension [TENS] was also associated with decreasing ventral anterior cingulate gyrus (AC) and anterior insula activity. More...
anterior insula		Increased agitation(tension)	symptoms	Brody, 2001	patients only		Improvement in anxiety/somatization [ANX] and tension [TENS]...... Improvement in anxiety/somatization [ANX] and tension [TENS] was also associated with decreasing ventral anterior cingulate gyrus (AC) and anterior insula activity. More...
contralateral anterior insula		Depressed mood(depression)	symptoms	Giesecke, 2005	patients and normal controls		Symptoms of depression and the presence of MDD were associat...... Symptoms of depression and the presence of MDD were associated with the magnitude of pain-evoked neuronal activations in brain regions associated with affective pain processing (the amygdalae and contralateral anterior insula). More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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