MK4MDD

Brain Morphology and Function Report

Basic Information
Name Ventral striatum
Brain Morphology "The ventral striatum is generally considered that part of the striatum that is connectionally associated with limbic structures, such as the amygdala, hippocampus, midline thalamus, and certain regions of the prefrontal cortex. In addition, the ventral striatum is strongly innervated by dopaminergic fibers from the ventral tegmental area (VTA), known as the mesolimbic dopamine system, and has the highest density of serotonergic inputs in the striatum. The ventral striatum consists of the nucleus accumbens and the olfactory tubercle. Although, some sources also include the ventromedial parts of the caudate nucleus and putamen."
Brain Function "In line with the characteristics of its inputs, the ventral striatum is functionally strongly associated with emotional and motivational aspects of behavior. Moreover, structural and functional disturbances of ventral striatal areas have been shown to be correlated with various forms of psychopathology, such as schizophrenia, addictive behavior, and obsessive-compulsive disorder. Based on the character of the afferents of the nucleus accumbens, the ventral striatum may be viewed as a site for integration of signals with emotional content (amygdala); contextual information (hippocampus); motivational significance (dopaminergic inputs); information about the state of arousal (midline thalamus); and executive/cognitive information (prefrontal cortex)."
No. of Studies (Positive/Negative) 10(10/0) Help

Positive relationships between Ventral striatum and MDD (count: 9)
Name in Literature Reference Research Type Statistical Result Relation Description Help
ventral striatum Fu, 2004 patients and normal controls Over time, depressed subjects showed reduced capacity for ac...... Over time, depressed subjects showed reduced capacity for activation in the ventral striatum. More...
ventral striatum Malone, 2009 patients only Significant improvements in depressive symptoms were observe...... Significant improvements in depressive symptoms were observed during deep brain stimulation (DBS) of the ventral striatum. More...
ventral striatum McCabe, 2009 patients and normal controls Patients showed decreased neural responses to the pleasant s...... Patients showed decreased neural responses to the pleasant stimulus in the ventral striatum. More...
ventral striatum Epstein, 2006 patients and normal controls Relative to comparison subjects, depressed patients demonstr...... Relative to comparison subjects, depressed patients demonstrated significantly less bilateral ventral striatal activation to positive stimuli. More...
ventral striatum Steele, 2007 patients and normal controls Depressed patients did not activated the ventral striatum to...... Depressed patients did not activated the ventral striatum to positive feedback. More...
ventral striatum Kumar, 2008 patients and normal controls Patients with MDD had significantly reduced reward-learning ...... Patients with MDD had significantly reduced reward-learning signals in ventral striatum. More...
ventral striatum Neumeister, 2004 patients and normal controls Compared with sham depletion, TD (tryptophan depletion) was ...... Compared with sham depletion, TD (tryptophan depletion) was associated with an increase in regional cerebral glucose utilization in the ventral striatum in patients with remitted MDD but not in controls. More...
ventral striatum (VS) Grimm, 2009 patients and normal controls Neurally, patients with MDD showed significantly lower signa...... Neurally, patients with MDD showed significantly lower signal intensities in various subcortical and cortical midline regions like the dorsomedial prefrontal cortex (DMPFC), supragenual anterior cingulate cortex, precuneus, ventral striatum (VS), and the dorsomedial thalamus (DMT). More...
ventral striatum Murrough, 2011 patients and normal controls 1.37 +/- 0.13 and 1.68 +/- 0.16, respectively; 18.7% between-group difference; P-value < 0.001 Within the ventral striatum/ventral pallidum region of inter...... Within the ventral striatum/ventral pallidum region of interest, 5-HT(1B) receptor radioligand [(11)C]P943 BP (ND) was significantly reduced in the MDD group compared with the healthy control group (1.37 +/- 0.13 and 1.68 +/- 0.16, respectively; 18.7% between-group difference; p < 0.001). More...

Positive relationships between Ventral striatum and other components at different levels (count: 4) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Ventral striatum in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Ventral striatum and MDD (count: 0)
Negative relationships between Ventral striatum and other components at different levels (count: 0) Help