"The ventral striatum is generally considered that part of the striatum that is connectionally associated with limbic structures, such as the amygdala, hippocampus, midline thalamus, and certain regions of the prefrontal cortex. In addition, the ventral striatum is strongly innervated by dopaminergic fibers from the ventral tegmental area (VTA), known as the mesolimbic dopamine system, and has the highest density of serotonergic inputs in the striatum. The ventral striatum consists of the nucleus accumbens and the olfactory tubercle. Although, some sources also include the ventromedial parts of the caudate nucleus and putamen."
"In line with the characteristics of its inputs, the ventral striatum is functionally strongly associated with emotional and motivational aspects of behavior. Moreover, structural and functional disturbances of ventral striatal areas have been shown to be correlated with various forms of psychopathology, such as schizophrenia, addictive behavior, and obsessive-compulsive disorder. Based on the character of the afferents of the nucleus accumbens, the ventral striatum may be viewed as a site for integration of signals with emotional content (amygdala); contextual information (hippocampus); motivational significance (dopaminergic inputs); information about the state of arousal (midline thalamus); and executive/cognitive information (prefrontal cortex)."
No. of Studies (Positive/Negative)
Positive relationships between Ventral striatum and MDD (count: 9)
Compared with sham depletion, TD (tryptophan depletion) was ......
Compared with sham depletion, TD (tryptophan depletion) was associated with an increase in regional cerebral glucose utilization in the ventral striatum in patients with remitted MDD but not in controls. More...
Neurally, patients with MDD showed significantly lower signa......
Neurally, patients with MDD showed significantly lower signal intensities in various subcortical and cortical midline regions like the dorsomedial prefrontal cortex (DMPFC), supragenual anterior cingulate cortex, precuneus, ventral striatum (VS), and the dorsomedial thalamus (DMT). More...
Within the ventral striatum/ventral pallidum region of inter......
Within the ventral striatum/ventral pallidum region of interest, 5-HT(1B) receptor radioligand [(11)C]P943 BP (ND) was significantly reduced in the MDD group compared with the healthy control group (1.37 +/- 0.13 and 1.68 +/- 0.16, respectively; 18.7% between-group difference; p < 0.001). More...
Positive relationships between Ventral striatum and other components at different levels (count: 4)
Protein and other molecule
Cell and molecular pathway
Cognition and behavior
Symptoms and signs
Positive relationship network of Ventral striatum in MK4MDD
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1. The different color of the nodes denotes the level of the nodes.
Protein and Other Molecule
Cell and Molecular Pathway
Cognition and Behavior
Symptoms and Signs
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node.
Right-click will show also the menus to link to the report page of the node and remove the node and related edges.
Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web
Negative relationships between Ventral striatum and MDD (count: 0)
Negative relationships between Ventral striatum and other components at different levels (count: 0)
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: October 10, 2015