MK4MDD

Pathway Report

Basic Information
Name T cell receptor signalling pathway
BioCarta Link ID: TCR_PATHWAY
Name: tcr pathway
Brief Description: T Cell Receptor Signaling Pathway
Full Description: The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alpha and beta chains (shown here) or gamma and delta chains in gamma/delta T Cells. It is the ability of this receptor to bind a complex of foreign peptide in the groove of an MHC molecule that leads to T cell activation. Upon activation the T cell can assist in activating other cells or carry out cytolytic attacks depending on the particular T cell type. The CD3 complex and CD4 (Th cells) or CD8 (Tc cells) work to transmit the activation signal to the T cell's transcriptional machinary upon engagement of the receptor.
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between T cell receptor signalling pathway and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
T cell receptor signalling pathway Kao CF, 2012 patients and normal controls We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

Positive relationships between T cell receptor signalling pathway and other components at different levels (count: 0) Help
Positive relationship network of T cell receptor signalling pathway in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between T cell receptor signalling pathway and MDD (count: 0)
Negative relationships between T cell receptor signalling pathway and other components at different levels (count: 0) Help
Pathway T cell receptor signalling pathway related genes in MK4MDD (count: 10)