Pathway Report

Name	T cell receptor signalling pathway
BioCarta Link	ID: TCR_PATHWAY Name: tcr pathway Brief Description: T Cell Receptor Signaling Pathway Full Description: The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alpha and beta chains (shown here) or gamma and delta chains in gamma/delta T Cells. It is the ability of this receptor to bind a complex of foreign peptide in the groove of an MHC molecule that leads to T cell activation. Upon activation the T cell can assist in activating other cells or carry out cytolytic attacks depending on the particular T cell type. The CD3 complex and CD4 (Th cells) or CD8 (Tc cells) work to transmit the activation signal to the T cell's transcriptional machinary upon engagement of the receptor.
No. of Studies (Positive/Negative)	1 (1/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
T cell receptor signalling pathway	Kao CF, 2012	patients and normal controls		We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Literature-origin	1(1/0)
CALM2	calmodulin 2 (phosphorylase kinase, delta)	Literature-origin	1(1/0)
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Protein mapped	0(0/0)
MAPK8	mitogen-activated protein kinase 8	Literature-origin	1(1/0)
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	Protein mapped	0(0/0)
JUN	jun proto-oncogene	Literature-origin	1(1/0)
PRKCB	protein kinase C, beta	Protein mapped	0(0/0)
FOS	FBJ murine osteosarcoma viral oncogene homolog	Literature-origin; Protein mapped	1(1/0)