Protein Report

Basic Information

Protein Name	Ribonucleoside-diphosphate reductase large subunit
UniPortKB	P23921
No. of Studies (Positive/Negative)	1 (1/0)
Type	Literature-origin

Positive relationship between Ribonucleoside-diphosphate reductase large subunit and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
R1	Johnson, 2011	patients and normal controls	P-value<0.005	Western blot analysis showed that R1 was significantly decre...... Western blot analysis showed that R1 was significantly decreased by 37.5% (p<0.005) in untreated MDD subjects. The R1 level in medicated MDD subjects was also significantly lower (by 30%; p<0.05) compared with control subjects, but was not significantly different compared with untreated MDD subjects. Interestingly, the reduction in R1 was significantly correlated with an increase (approximately 40%; p<0.05) in MAO A protein levels within the MDD groups compared with controls. More...

Positive relationships between Ribonucleoside-diphosphate reductase large subunit and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
R1		Amine oxidase [flavin-containing] A(monoamine oxidase A)	protein	Johnson, 2011	patients and normal controls	P-value<0.05	Western blot analysis showed that R1 was significantly decre...... Western blot analysis showed that R1 was significantly decreased by 37.5% (p<0.005) in untreated MDD subjects. The R1 level in medicated MDD subjects was also significantly lower (by 30%; p<0.05) compared with control subjects, but was not significantly different compared with untreated MDD subjects. Interestingly, the reduction in R1 was significantly correlated with an increase (approximately 40%; p<0.05) in MAO A protein levels within the MDD groups compared with controls. More...

Positive relationship network of Ribonucleoside-diphosphate reductase large subunit in MK4MDD

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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between Ribonucleoside-diphosphate reductase large subunit and MDD (count: 0)

Negative relationships between Ribonucleoside-diphosphate reductase large subunit and other components at different levels (count: 0)

Related Gene Info

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
RRM1	ribonucleotide reductase M1	Protein mapped	0 (0/0)