MK4MDD

Symptoms Report

Basic Information
Name Rhythm disturbances
Description "Circadian alterations (e.g., mood fluctuations, sleep disturbances) are a frequent clinical manifestation of depression as well as features reported in healthy volunteers in terms of diurnal variation in subjective measures of mood. Regarding depression, the classic symptom of the melancholic subtype of major depression is even represented by diurnal mood variation. In particular, the early morning worsening has been always considered as a melancholic features. The most studied circadian alterations in depression are sleep abnormalities, reported by 50-85% of patients. However, other blunted rhythms appear to be abnormal, such as central body temperature and hormonal rhythms, possibly linked to dysfunctions of the recently described clock-genes system (E. Gaspar-Barba, et al.2009. PMID: 19285347)."
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between Rhythm disturbances and MDD (count: 0)
Positive relationships between Rhythm disturbances and other components at different levels (count: 4) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Rhythm disturbances in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Rhythm disturbances and MDD (count: 0)
Negative relationships between Rhythm disturbances and other components at different levels (count: 0) Help