Protein Report

Protein Name	Pro-neuropeptide Y
UniPortKB	P01303
No. of Studies (Positive/Negative)	4 (3/1)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
neuropeptide Y	Irwin, 1991	patients and normal controls	P-value<0.01	Plasma levels of neuropeptide Y, but not circulating basal l...... Plasma levels of neuropeptide Y, but not circulating basal levels of catecholamines, were significantly (P less than 0.01) elevated in the depressed patients and in the caregivers compared with respective controls. More...
neuropeptide Y	Heilig M, 2004	Patients and nomal controls		A robust suppression of NPY levels in patient CSF was found,...... A robust suppression of NPY levels in patient CSF was found, while other putative CSF markers (monoamine metabolites, somatostatin) did not differ between the groups. More...
neuropeptide Y	Cizza, 2008	patients and normal controls		Proinflammatory cytokines, neuropeptide Y, substance P, and ...... Proinflammatory cytokines, neuropeptide Y, substance P, and calcitonin-gene-related peptide were significantly higher and vasoactive intestinal peptide, a marker of parasympathetic activity, was significantly lower in patients compared to controls More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
neuropeptide Y		Killer Cells, Natural(natural killer)	cell	Irwin, 1991	patients and normal controls	r = -0.31, P-value < 0.001	Circulating concentrations of neuropeptide Y, but not catech...... Circulating concentrations of neuropeptide Y, but not catecholamines, were inversely correlated (r = -0.31, P less than 0.001) with NK activity More...

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1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Pro-neuropeptide Y	Garcia FD, 2012	patients and normal controls		No significant differences in NPY IgG autoAb affinities betw...... No significant differences in NPY IgG autoAb affinities between patients with depression and controls were found More...

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
NPY	neuropeptide Y	Literature-origin; SNP mapped; Protein mapped	6 (5/1)