MK4MDD

Protein Report

Basic Information
Protein Name Pro-neuropeptide Y
UniPortKB P01303
No. of Studies (Positive/Negative) 4 (3/1) Help
Type Literature-origin
Positive relationship between Pro-neuropeptide Y and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description Help
neuropeptide Y Irwin, 1991 patients and normal controls P-value<0.01 Plasma levels of neuropeptide Y, but not circulating basal l...... Plasma levels of neuropeptide Y, but not circulating basal levels of catecholamines, were significantly (P less than 0.01) elevated in the depressed patients and in the caregivers compared with respective controls. More...
neuropeptide Y Heilig M, 2004 Patients and nomal controls A robust suppression of NPY levels in patient CSF was found,...... A robust suppression of NPY levels in patient CSF was found, while other putative CSF markers (monoamine metabolites, somatostatin) did not differ between the groups. More...
neuropeptide Y Cizza, 2008 patients and normal controls Proinflammatory cytokines, neuropeptide Y, substance P, and ...... Proinflammatory cytokines, neuropeptide Y, substance P, and calcitonin-gene-related peptide were significantly higher and vasoactive intestinal peptide, a marker of parasympathetic activity, was significantly lower in patients compared to controls More...

Positive relationships between Pro-neuropeptide Y and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Positive relationship network of Pro-neuropeptide Y in MK4MDD
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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Pro-neuropeptide Y and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
Pro-neuropeptide Y Garcia FD, 2012 patients and normal controls No significant differences in NPY IgG autoAb affinities betw...... No significant differences in NPY IgG autoAb affinities between patients with depression and controls were found More...

Negative relationships between Pro-neuropeptide Y and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
NPY neuropeptide Y Literature-origin; SNP mapped; Protein mapped 7 (6/1)