Gene Report

Basic Information

Approved Symbol	PPM1K
Approved Name	protein phosphatase, Mg2+/Mn2+ dependent, 1K
Previous Name	"protein phosphatase 1K (PP2C domain containing)"
Symbol Alias	DKFZp761G058, PP2Ckappa, hPTMP, PP2Cm, BDP
Name Alias	"PP2C-type mitochondrial phosphoprotein phosphatase", "protein phosphatase 2C kappa", "branched-chain α-ketoacid dehydrogenase phosphatase"
Location	4q22.1
Position	chr4:89205558-89205771 (-)
External Links	Entrez Gene: 152926 Ensembl: ENSG00000163644 UCSC: uc003hrm.5 HGNC ID: 25415
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PPM1K and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PPM1K	Sequeira, 2007	patients and normal controls		Selected differentially expressed genes in hippocampus Selected differentially expressed genes in hippocampus

Positive relationships between PPM1K and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
PPM1K		Hippocampus(hippocampus)	brain morphology and function	Sequeira, 2007	patients and normal controls		Selected differentially expressed genes in hippocampus Selected differentially expressed genes in hippocampus

Positive relationship network of PPM1K in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PPM1K and MDD (count: 0)

Negative relationships between PPM1K and other components at different levels (count: 0)

PPM1K related SNPs in MK4MDD (count: 0)

PPM1K related proteins in MK4MDD (count: 0)

PPM1K related GO terms (count: 9)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0009083	branched-chain amino acid catabolic process	biological process	TAS
GO:0006470	protein dephosphorylation	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[25416956]
GO:0005759	mitochondrial matrix	cellular component	TAS
GO:0046872	metal ion binding	molecular function	IEA
GO:0004722	protein serine/threonine phosphatase activity	molecular function	TAS
GO:0005739	mitochondrion	cellular component	IDA
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS

PPM1K related KEGG pathways (count: 0)

PPM1K related BioCarta pathways (count: 0)

PPM1K related Reactome pathways (count: 0)

PPM1K related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms