Pathway Report

Name	O-Glycan biosynthesis
KEGG Link	ID: hsa00512 Name: o glycan_biosynthesis Brief Description: O-Glycan biosynthesis Full Description: O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine.
No. of Studies (Positive/Negative)	1 (1/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
O-Glycan biosynthesis	Kao CF, 2012	patients and normal controls		We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

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Note:
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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	Literature-origin	1(1/0)