Brain Morphology and Function Report

Name	Dorsal raphe nucleus
Brain Morphology	The dorsal raphe nucleus is located on the midline of the brainstem and is part of the raphe nucleus, consisting of the rostral and caudal subdivisions. The dorsal raphe is the largest serotonergic nucleus and provides a substantial proportion of the serotonin innervation to the forebrain. A substantial population of cells synthesizing substance P are found in the rostral aspects, many of these co-express serotonin and substance P. There is also a population of catecholamine synthesizing neurons in the rostral dorsal raphe, and these cells appear to be relatively large.The dorsal raphe nucleus is rich in pre-synaptic serotonin 5-HT1A autoreceptors, and it's believed that the action of the selective serotonin reuptake inhibitors (SSRIs) in this region is responsible for the latency of their antidepressant effect.
Picture	From Wiki.
No. of Studies (Positive/Negative)	5(5/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
dorsal raphe nucleus	Meltzer, 2004	patients and normal controls	P-value = 0.0016	We used [11C]WAY 100635 and positron emission tomography (PE...... We used [11C]WAY 100635 and positron emission tomography (PET) to test our hypothesis that 5-HT(1A) receptor binding, We observed significantly diminished [11C]WAY 100635 binding in the DRN (dorsal raphe nucleus) in depressed (BP = 2.31+/-0.90) relative to control (BP = 3.69+/-1.56) subjects (p = 0.0016). More...
dorsal raphe nucleus	Bach-Mizrachi, 2006	patients and normal controls	33% higher in the DRN and 17% higher in the MRN	TPH2 expression is 33% higher in the DRN and 17% higher in t...... TPH2 expression is 33% higher in the DRN and 17% higher in the MRN as compared to matched nonpsychiatric controls More...
dorsal raphe nucleus	Goswami, 2010	patients and normal controls		We found that mRNA concentrations of the 5-HT1D receptor and...... We found that mRNA concentrations of the 5-HT1D receptor and the transcription factors, NUDR and REST, were significantly increased in DR-captured neurons of female MDD subjects compared to female control subjects More...
dorsal raphe nucleus	Matthews PR, 2012	patients and normal controls		In MDD, the area of the DRN was decreased In MDD, the area of the DRN was decreased

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
dorsal raphe nucleus		Depressed mood(depression)	symptoms	Meltzer, 2004	patients and normal controls	r = 0.60, P-value = 0.014	the DRN(dorsal raphe nucleus) BP(5-HT(1A) receptor binding )...... the DRN(dorsal raphe nucleus) BP(5-HT(1A) receptor binding ) was correlated with pretreatment Hamilton Depression Rating Scores (r = 0.60, p = 0.014) in the depressed cohort. More...
dorsal raphe nucleus		Feelings of hopelessness, worthlessness, and guilt(helplessness)	symptoms	McDevitt, 2011	animal model		The 5-HT(1B) autoreceptors originating in the caudal DRN reg...... The 5-HT(1B) autoreceptors originating in the caudal DRN regulate behavioral expression of helplessness and fear.Overexpression of 5-HT(1B) in the caudal DRN increased swimming in the forced swim test. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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