MK4MDD

Brain Morphology and Function Report

Basic Information
Name Dorsal raphe nucleus
Brain Morphology "The dorsal raphe nucleus is located on the midline of the brainstem and is part of the raphe nucleus, consisting of the rostral and caudal subdivisions. The dorsal raphe is the largest serotonergic nucleus and provides a substantial proportion of the serotonin innervation to the forebrain. A substantial population of cells synthesizing substance P are found in the rostral aspects, many of these co-express serotonin and substance P. There is also a population of catecholamine synthesizing neurons in the rostral dorsal raphe, and these cells appear to be relatively large.The dorsal raphe nucleus is rich in pre-synaptic serotonin 5-HT1A autoreceptors, and it's believed that the action of the selective serotonin reuptake inhibitors (SSRIs) in this region is responsible for the latency of their antidepressant effect."
Picture Dorsal raphe nucleus From Wiki. Magnify
No. of Studies (Positive/Negative) 5(5/0) Help

Positive relationships between Dorsal raphe nucleus and MDD (count: 4)
Name in Literature Reference Research Type Statistical Result Relation Description Help
dorsal raphe nucleus Meltzer, 2004 patients and normal controls P-value = 0.0016 We used [11C]WAY 100635 and positron emission tomography (PE...... We used [11C]WAY 100635 and positron emission tomography (PET) to test our hypothesis that 5-HT(1A) receptor binding, We observed significantly diminished [11C]WAY 100635 binding in the DRN (dorsal raphe nucleus) in depressed (BP = 2.31+/-0.90) relative to control (BP = 3.69+/-1.56) subjects (p = 0.0016). More...
dorsal raphe nucleus Bach-Mizrachi, 2006 patients and normal controls 33% higher in the DRN and 17% higher in the MRN TPH2 expression is 33% higher in the DRN and 17% higher in t...... TPH2 expression is 33% higher in the DRN and 17% higher in the MRN as compared to matched nonpsychiatric controls More...
dorsal raphe nucleus Goswami, 2010 patients and normal controls We found that mRNA concentrations of the 5-HT1D receptor and...... We found that mRNA concentrations of the 5-HT1D receptor and the transcription factors, NUDR and REST, were significantly increased in DR-captured neurons of female MDD subjects compared to female control subjects More...
dorsal raphe nucleus Matthews PR, 2012 patients and normal controls In MDD, the area of the DRN was decreased In MDD, the area of the DRN was decreased

Positive relationships between Dorsal raphe nucleus and other components at different levels (count: 2) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Dorsal raphe nucleus in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Dorsal raphe nucleus and MDD (count: 0)
Negative relationships between Dorsal raphe nucleus and other components at different levels (count: 0) Help