Protein Report

Protein Name	Disrupted in schizophrenia 1 protein
UniPortKB	Q9NRI5
No. of Studies (Positive/Negative)	2 (2/0)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
DISC1	Sawamura N, 2005	Patients and nomal controls		In the the subcellular distribution of this DISC1 isoform,...... In the the subcellular distribution of this DISC1 isoform, assessed by the nuclear to cytoplasmic ratio in the immunoreactivity of the isoform, is significantly changed in brains from patients with SZ and MD. This altered distribution is also observed in those subjects with substance and alcohol abuse. The changes in MD brains are significantly influenced by substance/alcohol abuse as well as postmortem interval; however, the alteration in SZ brains is free from brain-associated confounding factors, although an interaction with substance/alcohol abuse cannot be completely ruled out. More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
DISC1		protein kinase B signaling cascade(Akt)	pathway	Hashimoto, 2006	patients and normal controls; cell model		In primary neuronal culture, knockdown of endogenous DISC1 p...... In primary neuronal culture, knockdown of endogenous DISC1 protein by small interfering RNA resulted in the suppression of phosphorylation of ERK and Akt, whose signaling pathways are implicated in MDD. More...
DISC1		mapkkk cascade(ERK)	pathway	Hashimoto, 2006	patients and normal controls; cell model		In primary neuronal culture, knockdown of endogenous DISC1 p...... In primary neuronal culture, knockdown of endogenous DISC1 protein by small interfering RNA resulted in the suppression of phosphorylation of ERK and Akt, whose signaling pathways are implicated in MDD. When effects of sDISC1 (Ser704) and cDISC1 (Cys704) proteins were examined separately, phosphorylation of ERK was greater in sDISC1 compared with cDISC1. More...
DISC1		Orbitofrontal cortex(orbitofrontal cortex)	brain morphology and function	Sawamura N, 2005	Patients and nomal controls		In the the subcellular distribution of this DISC1 isoform,...... In the the subcellular distribution of this DISC1 isoform, assessed by the nuclear to cytoplasmic ratio in the immunoreactivity of the isoform, is significantly changed in brains from patients with SZ and MD. This altered distribution is also observed in those subjects with substance and alcohol abuse. The changes in MD brains are significantly influenced by substance/alcohol abuse as well as postmortem interval; however, the alteration in SZ brains is free from brain-associated confounding factors, although an interaction with substance/alcohol abuse cannot be completely ruled out. More...

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1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
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Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
DISC1	disrupted in schizophrenia 1	Literature-origin; SNP mapped; Protein mapped	2 (2/0)