Signs Report

Name	Cortisol awakening response
Description	The cortisol awakening response (CAR) is an increase of about 50% in cortisol levels occurring 20-30 minutes after awakening in the morning in some people. This rise is superimposed upon the late-night rise in cortisol which occurs before awakening. It is thought to be linked to the hippocampus' preparation of the hypothalamic-pituitary-adrenal axis (HPA) to face anticipated stress.
No. of Studies (Positive/Negative)	3 (3/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
cortisol response	Rydmark, 2006	patients and normal controls	P-value = .002	The cortisol response to CRH (corticotropin-releasing hormon...... The cortisol response to CRH (corticotropin-releasing hormone) differed markedly between the two groups (p = .002), with a dampened response in patients. More...
cortisol awakening response	Vreeburg, 2009	patients and normal controls	effect size [Cohen d] range, 0.15-0.25	Both the remitted and current MDD groups showed a significan...... Both the remitted and current MDD groups showed a significantly higher cortisol awakening response compared with control subjects (effect size [Cohen d] range, 0.15-0.25). More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
cortisol awakening response (CAR)		NR3C2(MR)	gene	Klok, 2011	patients and normal controls	P-value=0.03	MR -2C/C genotype was associated with an attenuated CAR incr...... MR -2C/C genotype was associated with an attenuated CAR increase in women (p=.03) but not in men (p=.18; p=.01 for SNP-by-sex interaction). The MR I180V SNP had no significant effect on the CAR. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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