Neurobiological Component Report

Name	Cholinergic system
Description	Cholinergic typically refers to acetylcholine in a neurological perspective. In neuroscience and related fields, the term cholinergic is used in the following related contexts: A substance (or ligand) is cholinergic if it is capable of producing, altering, or releasing acetylcholine ("indirect-acting") or mimicking its behaviour at one or more of the body's acetylcholine receptor types ("direct-acting"). A receptor is cholinergic if it uses acetylcholine as its neurotransmitter. A synapse is cholinergic if it uses acetylcholine as its neurotransmitter.
No. of Studies (Positive/Negative)	1 (1/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
cholinergic systems	Rao, 2004	patients only		The findings suggest that the dysregulation in cholinergic s...... The findings suggest that the dysregulation in cholinergic systems associated with depressive illness may be persistent during remission, at least for some cholinergic systems. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
cholinergic systems		Hydrocortisone(cortisol)	molecule	Rao, 2004	patients only		The results also suggest that the central cholinergic system...... The results also suggest that the central cholinergic system(s) that regulate(s) REM sleep may be more sensitive to dysregulation than the cholinergic system(s) that control(s) nocturnal cortisol secretion. More...
cholinergic systems		Rapid eye movement (REM) sleep(rapid eye movement (REM) sleep)	neurobiological system	Rao, 2004	patients only		The results also suggest that the central cholinergic system...... The results also suggest that the central cholinergic system(s) that regulate(s) REM sleep may be more sensitive to dysregulation than the cholinergic system(s) that control(s) nocturnal cortisol secretion. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Name	Type
acetylcholine	molecule
acetylcholine receptor	protein