Gene Report

Basic Information

Approved Symbol	CPM
Approved Name	carboxypeptidase M
Name Alias	"renal carboxypeptidase", "urinary carboxypeptidase B"
Location	12q15
Position	chr12:69356949-69357020 (-)
External Links	Entrez Gene: 1368 Ensembl: ENSG00000135678 UCSC: uc001suq.3 HGNC ID: 2311
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CPM and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CPM	Chu TT, 2009	Patients and nomal controls		Down regulation, fold change([MD] vs [C]) 2.4434388 Down regulation, fold change([MD] vs [C]) 2.4434388

Positive relationships between CPM and other components at different levels (count: 0)

Positive relationship network of CPM in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CPM and MDD (count: 0)

Negative relationships between CPM and other components at different levels (count: 0)

CPM related SNPs in MK4MDD (count: 0)

CPM related proteins in MK4MDD (count: 0)

CPM related GO terms (count: 12)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006518	peptide metabolic process	biological process	IBA
GO:0009653	anatomical structure morphogenesis	biological process	TAS[7797563]
GO:0005615	extracellular space	cellular component	IBA
GO:0004181	metallocarboxypeptidase activity	molecular function	IEA
GO:0004185	serine-type carboxypeptidase activity	molecular function	IBA
GO:0009986	cell surface	cellular component	IDA[19581412]
GO:0016485	protein processing	biological process	IBA
GO:0070062	extracellular exosome	cellular component	IDA[23376485\|23533145]
GO:0031225	anchored component of membrane	cellular component	IEA
GO:0004180	carboxypeptidase activity	molecular function	TAS[7797563]
GO:0008270	zinc ion binding	molecular function	IEA
GO:0005886	plasma membrane	cellular component	IEA

CPM related KEGG pathways (count: 0)

CPM related BioCarta pathways (count: 0)

CPM related Reactome pathways (count: 0)

CPM related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CPM	EGF	Yes	in vivo	7615511 , 8796265
CPM	HBA2	Yes	in vitro	8635221

Gene Report

Gene mapped GO terms