Gene Report

Basic Information

Approved Symbol	HBA2
Approved Name	hemoglobin, alpha 2
Location	16p13.3
Position	chr16:222846-223709 (+)
External Links	Entrez Gene: 3040 Ensembl: ENSG00000188536 UCSC: uc002cfv.4 HGNC ID: 4824
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between HBA2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
HBA2	Chu TT, 2009	Patients and nomal controls		Up regulation, fold change([MD] vs [C]) 2.9828923 Up regulation, fold change([MD] vs [C]) 2.9828923

Positive relationships between HBA2 and other components at different levels (count: 0)

Positive relationship network of HBA2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between HBA2 and MDD (count: 0)

Negative relationships between HBA2 and other components at different levels (count: 0)

HBA2 related SNPs in MK4MDD (count: 0)

HBA2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Hemoglobin subunit alpha	P69905	0(0/0)	Gene mapped

HBA2 related GO terms (count: 18)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0031838	haptoglobin-hemoglobin complex	cellular component	IDA[19740759]
GO:0005829	cytosol	cellular component	TAS
GO:0020037	heme binding	molecular function	IEA
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0004601	peroxidase activity	molecular function	IDA[19740759]
GO:0010942	positive regulation of cell death	biological process	IDA[19740759]
GO:0005833	hemoglobin complex	cellular component	IDA[19740759]; TAS[7555018]
GO:0051291	protein heterooligomerization	biological process	IDA[19740759]
GO:0031720	haptoglobin binding	molecular function	IDA[19740759]
GO:0042542	response to hydrogen peroxide	biological process	IDA[19740759]
GO:0015701	bicarbonate transport	biological process	TAS
GO:0005506	iron ion binding	molecular function	IEA
GO:0005515	protein binding	molecular function	IPI[16169070]
GO:0005344	oxygen transporter activity	molecular function	IEA
GO:0022627	cytosolic small ribosomal subunit	cellular component	IDA[8706699]
GO:0015671	oxygen transport	biological process	TAS[7518430]
GO:0042744	hydrogen peroxide catabolic process	biological process	IDA[19740759]
GO:0019825	oxygen binding	molecular function	IEA

HBA2 related KEGG pathways (count: 0)

HBA2 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
AHSP_PATHWAY	ahsp pathway	Hemoglobin's Chaperone	The function of hemoglobin in oxygen transport by red blood ...... The function of hemoglobin in oxygen transport by red blood cells requires precise assembly of a tetramer of two beta-subunits and two alpha-units. If too many beta-subunits are present, then all tetramers of beta-subunits are formed that bind oxygen but do not release it when needed. When alpha-subunits are in excess they form precipitates with oxidized heme that damage red blood cells. Red blood cells require a precise coregulation of alpha and beta subunit expression to maintain the proper ratio of the subunits and normal red blood cell function. Generally red blood cells express slightly more alpha than beta-subunits to avoid forming unproductive beta-tetramers (HbH). The slight excess of alpha units are blocked from precipitation by a molecular chaperone, AHSP, alpha-hemoglobin stabilizing protein. Expression of the AHSP gene is coordinately activated with the globin genes and heme biosynthesis genes by the GATA-1 gene involved in erythrocyte differentiation. AHSP blocks precipitation of alpha-units, and promotes the formation of normal productive alpha-beta tetramers (HbA). People with mutation or deletion of the beta-subunit gene have Beta-thalassemias resulting from an over-abundance of alpha subunits and their precipitation. The severity of the phenotype may depend on the AHSP genotype of these individuals and elevating AHSP levels through gene therapy may provide a treatment strategy for beta-thalassemia. More...

HBA2 related Reactome pathways (count: 0)

HBA2 related interactors from protein-protein interaction data in HPRD (count: 5)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
HBA2	HBA2	Yes	in vitro	1512262 , 6726807 , 6644819
HBA2	HBB	No	in vitro	10930828 , 12122004 , 8980683
HBA2	HBE1	No	in vitro	9665850
HBA2	CPM	Yes	in vitro	8635221
HBA2	AHSP	No	in vitro;in vivo;yeast 2-hybrid	12192002 , 15550245

Gene Report

Gene mapped GO terms

Gene mapped BioCarta pathways