Protein Report

Protein Name	C-reactive protein
UniPortKB	P02741
No. of Studies (Positive/Negative)	8 (8/0)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
C-reactive protein (CRP)	Kling, 2007	patients and normal controls	P-value<0.01	Both SAA (5.30 +/- 3.39 vs. 2.84 +/- 1.87 mg/L, p < .005) an...... Both SAA (5.30 +/- 3.39 vs. 2.84 +/- 1.87 mg/L, p < .005) and CRP(hs) (3.23 +/- 3.17 vs. 1.12 +/- 1.45 mg/L; p < .01) were significantly elevated in MDD women versus controls. More...
C-reactive protein	Surtees, 2008	patients and normal controls		Past-year MDD was associated with increased CRP concentratio...... Past-year MDD was associated with increased CRP concentration levels (4.31 mg/L for participants who reported episodes of MDD in the past year versus 3.65 mg/L for those who did not; p = .003) More...
C-reactive protein (CRP)	Su, 2009	high-risk people	P-value<0.005	An association was observed between severity of current depr...... An association was observed between severity of current depressive symptoms and increased levels of inflammatory markers (p < .001 for IL-6 and p = .005 for CRP). More...
C-reactive protein	Cizza, 2009	patients and normal controls	P-value=0.077	These women tended to have consistently higher CRP levels th...... These women tended to have consistently higher CRP levels than controls over 12 months (p=0.077). More...
C-reactive protein	Pasco, 2010	patients and normal controls	HR = 1.44, 95% CI 1.04-1.99	The hazard ratio (HR) for depression increased by 44% for ea...... The hazard ratio (HR) for depression increased by 44% for each standard deviation increase in log-transformed hsCRP (ln-hsCRP) (HR = 1.44, 95% CI 1.04-1.99) More...
C-reactive protein (CRP)	Einvik, 2011	patients and normal controls	unstandardized beta = 0.387, P-value = 0.04	MDD was independently associated with CRP (unstandardized be...... MDD was independently associated with CRP (unstandardized beta = 0.387, p = .04) More...
CRP	Hughes MM, 2012	patients and normal controls		Whilst no changes in TNF-alpha or IL-1beta were observed, pl...... Whilst no changes in TNF-alpha or IL-1beta were observed, plasma concentrations of IL-6, IFN-gamma and CRP were increased in the depressed cohort. More...
CRP	Crnkovic D, 2012	patients and normal controls		Study results showed a statistically significant difference ...... Study results showed a statistically significant difference in the concentrations of inflammatory markers (C-reactive protein (CRP), interleukin-6 and tumor necrosis factor alpha) between the group of MDD subjects and control group of healthy subjects. These concentrations were higher in MDD subjects. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
CRP	C-reactive protein, pentraxin-related	Literature-origin; Protein mapped	1 (1/0)