Protein Report

Protein Name	C-reactive protein
UniPortKB	P02741
No. of Studies (Positive/Negative)	9 (8/1)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
C-reactive protein (CRP)	Kling, 2007	patients and normal controls	P-value<0.01	Both SAA (5.30 +/- 3.39 vs. 2.84 +/- 1.87 mg/L, p < .005) an...... Both SAA (5.30 +/- 3.39 vs. 2.84 +/- 1.87 mg/L, p < .005) and CRP(hs) (3.23 +/- 3.17 vs. 1.12 +/- 1.45 mg/L; p < .01) were significantly elevated in MDD women versus controls. More...
C-reactive protein	Surtees, 2008	patients and normal controls		Past-year MDD was associated with increased CRP concentratio...... Past-year MDD was associated with increased CRP concentration levels (4.31 mg/L for participants who reported episodes of MDD in the past year versus 3.65 mg/L for those who did not; p = .003) More...
C-reactive protein (CRP)	Su, 2009	high-risk people	P-value<0.005	An association was observed between severity of current depr...... An association was observed between severity of current depressive symptoms and increased levels of inflammatory markers (p < .001 for IL-6 and p = .005 for CRP). More...
C-reactive protein	Cizza, 2009	patients and normal controls	P-value=0.077	These women tended to have consistently higher CRP levels th...... These women tended to have consistently higher CRP levels than controls over 12 months (p=0.077). More...
C-reactive protein	Pasco, 2010	patients and normal controls	HR = 1.44, 95% CI 1.04-1.99	The hazard ratio (HR) for depression increased by 44% for ea...... The hazard ratio (HR) for depression increased by 44% for each standard deviation increase in log-transformed hsCRP (ln-hsCRP) (HR = 1.44, 95% CI 1.04-1.99) More...
C-reactive protein (CRP)	Einvik, 2011	patients and normal controls	unstandardized beta = 0.387, P-value = 0.04	MDD was independently associated with CRP (unstandardized be...... MDD was independently associated with CRP (unstandardized beta = 0.387, p = .04) More...
CRP	Hughes MM, 2012	patients and normal controls		Whilst no changes in TNF-alpha or IL-1beta were observed, pl...... Whilst no changes in TNF-alpha or IL-1beta were observed, plasma concentrations of IL-6, IFN-gamma and CRP were increased in the depressed cohort. More...
CRP	Crnkovic D, 2012	patients and normal controls		Study results showed a statistically significant difference ...... Study results showed a statistically significant difference in the concentrations of inflammatory markers (C-reactive protein (CRP), interleukin-6 and tumor necrosis factor alpha) between the group of MDD subjects and control group of healthy subjects. These concentrations were higher in MDD subjects. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CRP	Cubala WJ, 2014	patients and normal controls		No significant difference in CRP concentration between MDD a...... No significant difference in CRP concentration between MDD and control groups was found. More...

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
CRP	C-reactive protein, pentraxin-related	Literature-origin; Protein mapped	1 (1/0)