MK4MDD

Protein Report

Basic Information
Protein Name C-reactive protein
UniPortKB P02741
No. of Studies (Positive/Negative) 9 (8/1) Help
Type Literature-origin
Positive relationship between C-reactive protein and MDD (count: 8)
Name in Literature Reference Research Type Statistical Result Relation Description Help
C-reactive protein (CRP) Kling, 2007 patients and normal controls P-value<0.01 Both SAA (5.30 +/- 3.39 vs. 2.84 +/- 1.87 mg/L, p < .005) an...... Both SAA (5.30 +/- 3.39 vs. 2.84 +/- 1.87 mg/L, p < .005) and CRP(hs) (3.23 +/- 3.17 vs. 1.12 +/- 1.45 mg/L; p < .01) were significantly elevated in MDD women versus controls. More...
C-reactive protein Surtees, 2008 patients and normal controls Past-year MDD was associated with increased CRP concentratio...... Past-year MDD was associated with increased CRP concentration levels (4.31 mg/L for participants who reported episodes of MDD in the past year versus 3.65 mg/L for those who did not; p = .003) More...
C-reactive protein (CRP) Su, 2009 high-risk people P-value<0.005 An association was observed between severity of current depr...... An association was observed between severity of current depressive symptoms and increased levels of inflammatory markers (p < .001 for IL-6 and p = .005 for CRP). More...
C-reactive protein Cizza, 2009 patients and normal controls P-value=0.077 These women tended to have consistently higher CRP levels th...... These women tended to have consistently higher CRP levels than controls over 12 months (p=0.077). More...
C-reactive protein Pasco, 2010 patients and normal controls HR = 1.44, 95% CI 1.04-1.99 The hazard ratio (HR) for depression increased by 44% for ea...... The hazard ratio (HR) for depression increased by 44% for each standard deviation increase in log-transformed hsCRP (ln-hsCRP) (HR = 1.44, 95% CI 1.04-1.99) More...
C-reactive protein (CRP) Einvik, 2011 patients and normal controls unstandardized beta = 0.387, P-value = 0.04 MDD was independently associated with CRP (unstandardized be...... MDD was independently associated with CRP (unstandardized beta = 0.387, p = .04) More...
CRP Hughes MM, 2012 patients and normal controls Whilst no changes in TNF-alpha or IL-1beta were observed, pl...... Whilst no changes in TNF-alpha or IL-1beta were observed, plasma concentrations of IL-6, IFN-gamma and CRP were increased in the depressed cohort. More...
CRP Crnkovic D, 2012 patients and normal controls Study results showed a statistically significant difference ...... Study results showed a statistically significant difference in the concentrations of inflammatory markers (C-reactive protein (CRP), interleukin-6 and tumor necrosis factor alpha) between the group of MDD subjects and control group of healthy subjects. These concentrations were higher in MDD subjects. More...

Positive relationships between C-reactive protein and other components at different levels (count: 0) Help
Positive relationship network of C-reactive protein in MK4MDD
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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between C-reactive protein and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
CRP Cubala WJ, 2014 patients and normal controls No significant difference in CRP concentration between MDD a...... No significant difference in CRP concentration between MDD and control groups was found. More...

Negative relationships between C-reactive protein and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
CRP C-reactive protein, pentraxin-related Literature-origin; Protein mapped 1 (1/0)