Brain Morphology and Function Report

Name	Brainstem
Brain Morphology	The brainstem is the posterior part of the brain, adjoining and structurally continuous with the spinal cord. The brain stem is made of the midbrain, pons, and medulla.
Brain Function	Brain stem is responsible for basic vital life functions such as breathing, heartbeat, and blood pressure.
Picture	Source
No. of Studies (Positive/Negative)	6(6/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
brainstem	Kumar, 2008	patients and normal controls		The TD (temporal difference) signal was increased in the bra...... The TD (temporal difference) signal was increased in the brainstem of depressed patients. More...
brain stem	Kimbrell, 2002	patients and normal controls		Compared with control subjects, the subgroup of patients wit...... Compared with control subjects, the subgroup of patients with Hamilton depression scores of 22 or greater exhibited increased normalized metabolic activity bilaterally in the brain stem. More...
brainstem	Agid, 2003	patients and normal controls	P-value = 0.004	Mean volume of T2-WIH was significantly greater (p=0.004) in...... Mean volume of T2-WIH was significantly greater (p=0.004) in depressed subjects. In the control group T2-WIH(T2-weighted image 'hyperintensities') were exclusively located in the supratentorial hemispheral white matter while in the depressed group T2-WIH were also found in basal ganglia, temporal lobe, cerebellum and brainstem. More...
brainstem	Walter, 2007	patients and normal controls		Transcranial sonography (TCS) revealed reduced brainstem rap...... Transcranial sonography (TCS) revealed reduced brainstem raphe (BR) echogenicity in major depressive disorder (MDD). More...
brain stem	Selvaraj, 2011	patients and normal controls		The depressed patients had lowered 5-HTT binding in several ...... The depressed patients had lowered 5-HTT binding in several brain regions including brain stem More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
brainstem		Tryptophan 5-hydroxylase 2(TPH2)	protein	Haghighi, 2008	patients and normal controls		Here, we identify a novel TPH2 short isoform with truncated ...... Here, we identify a novel TPH2 short isoform with truncated catalytic domain expressed in human brainstem, prefrontal cortex, hippocampus and amygdala. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web