Protein Report

Basic Information

Protein Name	5-hydroxytryptamine receptor 1B
UniPortKB	P28222
No. of Studies (Positive/Negative)	2 (2/0)
Type	Literature-origin

Positive relationship between 5-hydroxytryptamine receptor 1B and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
5-HT(1B) receptor	Murrough, 2011	patients and normal controls	P-value < 0.001	Within the ventral striatum/ventral pallidum region of inter...... Within the ventral striatum/ventral pallidum region of interest, 5-HT(1B) receptor radioligand [(11)C]P943 BP (ND) was significantly reduced in the MDD group compared with the healthy control group (1.37 +/- 0.13 and 1.68 +/- 0.16, respectively; 18.7% between-group difference; p < 0.001). More...

Positive relationships between 5-hydroxytryptamine receptor 1B and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
serotonin 1B receptor		Protein S100-A10(p11)	protein	Svenningsson, 2006	animal model; patients and normal controls		p11 increases localization of 5-HT1B receptors at the cell s...... p11 increases localization of 5-HT1B receptors at the cell surface More...

Positive relationship network of 5-hydroxytryptamine receptor 1B in MK4MDD

Network loading ...

network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between 5-hydroxytryptamine receptor 1B and MDD (count: 0)

Negative relationships between 5-hydroxytryptamine receptor 1B and other components at different levels (count: 0)

Related Gene Info

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	Literature-origin; SNP mapped; Protein mapped	5 (4/1)