Study Report
Reference
| Citation | Lemogne, 2009 PubMed |
| Full Info | Lemogne, C., le Bastard, G., Mayberg, H., Volle, E., Bergouignan, L., Lehericy, S., Allilaire, J.F. and Fossati, P. (2009) In search of the depressive self: extended medial prefrontal network during self-referential processing in major depression. Soc Cogn Affect Neurosci, 4, 305-312.
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Study
| Hypothesis or Background |
Major depression is associated with an excessive self-focus, a tendency to engage oneself in self-referential processing. The medial frontal gyrus (MFG) is central to self-referential processing. This study aimed to explore the neural bases of this excessive self-focus and to disambiguate the role of the MFG in the pathophysiology of major depression.
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| Sample Information | 15 depressed patients and 15 healthy subjects |
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| Method Detail | We presented 15 depressed patients and 15 healthy subjects with personality traits during functional magnetic resonance imaging and asked them to judge whether each trait described them ('self' condition) or a generally desirable trait ('general' condition). |
| Method Keywords | functional magnetic resonance imaging (fMRI) |
| Result | Both patients and healthy subjects activated the MFG in 'self' vs 'general' condition. However, the activation of the dorsal part of the MFG and of the dorsolateral prefrontal cortex (DLPFC) in 'self' vs 'general' condition was unique to patients. Additionally, patients displayed an increased functional connectivity between the MFG, the dorsal anterior cingulate cortex and the DLPFC. |
| Conclusions | These results provide evidence for an extended medial prefrontal network during self-referential processing in major depression, suggesting the involvement of a greater cognitive control |
Relationships reported by
Lemogne, 2009
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Medial frontal gyrus (medial frontal gyrus) |
brain morphology and function |
|
Both patients and healthy subjects activated the MFG in 'self' vs 'general' condition. However, the activation of the dorsal part of the MFG (medial frontal gyrus) and of the dorsolateral prefrontal cortex (DLPFC) in 'self' vs 'general' condition was unique to patients. |
Positive
|
|
MDD
|
syndrome |
Dorsolateral prefrontal cortex (dorsolateral prefrontal cortex) |
brain morphology and function |
|
Both patients and healthy subjects activated the MFG in 'self' vs 'general' condition. However, the activation of the dorsal part of the MFG (medial frontal gyrus) and of the dorsolateral prefrontal cortex (DLPFC) in 'self' vs 'general' condition was unique to patients. |
Positive
|
