Study Report
Reference
| Citation | Lai, 2001 PubMed |
| Full Info | Lai, I.C., Hong, C.J. and Tsai, S.J. (2001) Association study of nicotinic-receptor variants and major depressive disorder. J Affect Disord, 66, 79-82.
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Study
| Hypothesis or Background |
Depressive patients are more likely to smoke than the general population and nicotine was found to reduce the incidence and severity of depressive symptoms in many studies. These findings suggest that nicotinic acetylcholine receptors (nAChRs) may be implicated in major depressive disorder. We tested the hypothesis that the allelic variant, 2 bp deletion, of the partially duplicated alpha7 nAChR gene confers susceptibility to major depressive disorder
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| Sample Information | 72 patients with major depressive disorder and 103 normal controls |
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| Method Detail | We genotyped alpha7 nAChR in 72 patients with major depressive disorder and 103 normal controls. |
| Method Keywords | genotyping |
| Result | The distribution of the partially duplicated alpha7 nAChR genotypes (P=0.027) and alleles (P=0.037) suggests a modest difference between depressive patients and controls. |
| Conclusions | The -2 bp allele of partially duplicated alpha7 nAChR may have an influence on the risk for development of major depressive disorder. The levels of significance achieved are modest and the findings must be replicated in other studies. |
Relationships reported by
Lai, 2001
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
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syndrome |
CHRNA7 (nAChRs) |
gene |
P-value<0.05 |
The distribution of the partially duplicated alpha7 nAChR genotypes (P=0.027) and alleles (P=0.037) suggests a modest difference between depressive patients and controls. |
Positive
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