Study Report
Reference
| Citation | Scantamburlo, 2007 PubMed |
| Full Info | Scantamburlo, G., Hansenne, M., Fuchs, S., Pitchot, W., Marechal, P., Pequeux, C., Ansseau, M. and Legros, J.J. (2007) Plasma oxytocin levels and anxiety in patients with major depression. Psychoneuroendocrinology, 32, 407-410.
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Study
| Hypothesis or Background |
Cerebrospinal fluid and plasmatic levels of oxytocin (OT) have been found to change in mood disorders. In post-mortem studies, the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased. Moreover, OT is considered as an endogenous antistress hormone. It has also revealed antidepressive effects. OT may contribute to the dysregulation of the HPA system in major depression.
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| Sample Information | depressive patients |
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| Method Detail | The aim of the study was to assess a possible relationship between anxiety and plasma oxytocin (OT) levels in depressive patients. Severity of depression was estimated with the Hamilton Depression Rating Scale and anxiety by using the Spielberger State-Anxiety Inventory. |
| Method Keywords | blood analysis |
| Result | Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r=-0.58, p=0.003) and anxiety (r=-0.61, p=0.005). |
Relationships reported by
Scantamburlo, 2007
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
Increased agitation (anxiety)
|
symptoms |
Oxytocin-neurophysin 1 (oxytocin) |
protein |
r=-0.61, P-value=0.005 |
Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r=-0.58, p=0.003) and anxiety (r=-0.61, p=0.005). |
Positive
|
|
Depressed mood (depression)
|
symptoms |
Oxytocin-neurophysin 1 (oxytocin) |
protein |
r=-0.58, P-value=0.003 |
Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r=-0.58, p=0.003) and anxiety (r=-0.61, p=0.005). |
Positive
|
