Study Report
Reference
| Citation | Leo, 2006 PubMed |
| Full Info | Leo, R., Di Lorenzo, G., Tesauro, M., Cola, C., Fortuna, E., Zanasi, M., Troisi, A., Siracusano, A., Lauro, R. and Romeo, F. (2006) Decreased plasma adiponectin concentration in major depression. Neurosci Lett, 407, 211-213.
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Study
| Hypothesis or Background |
Adiponectin is the most abundant adipose-derived plasma protein. Recently adiponectin levels have been linked to most variables of metabolic syndrome and conventional risk factors for cardiovascular disease. However, its relation with major depression is yet unclear.
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| Sample Information | 32 first-episode drug-naive major depression (DSM-IV-TR) patients without conventional risk factors for cardiovascular disease and 32 matched healthy subjects |
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| Method Detail | We evaluated plasma adiponectin levels in 32 first-episode drug-naive major depression (DSM-IV-TR) patients without conventional risk factors for cardiovascular disease and 32 matched healthy subjects. |
| Method Keywords | blood analysis |
| Result | Major depression patients displayed lower adiponectin plasma levels compared to controls (P<0.01). Adiponectin significantly correlated with depression severity, as assessed by HAM-D (rho=0.83, P<0.001) |
| Conclusions | This study shows decreased plasma adiponectin concentrations in major depression patients and relates adiponectinemia reduction to major depression severity. |
Relationships reported by
Leo, 2006
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
|
syndrome |
Adiponectin (adiponectin) |
protein |
P-value<0.01 |
Major depression patients displayed lower adiponectin plasma levels compared to controls (P<0.01). Adiponectin significantly correlated with depression severity, as assessed by HAM-D (rho=0.83, P<0.001). |
Positive
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