MK4MDD

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Study Report

Reference

Citation	Roessner, 2006 PubMed
Full Info	Roessner, V., Weber, A., Becker, A., Beck, G., Kornhuber, J., Frieling, H. and Bleich, S. (2006) Decreased serum semicarbazide sensitive aminooxidase (SSAO) activity in patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry, 30, 906-909.

Study

Hypothesis or Background	Semicarbazide sensitive aminooxidase (SSAO) is known to interplay with monoamine oxidases (MAO) and several antidepressants. Taking into account the monoamine hypothesis concerning the pathophysiology of depression, the aim of the present pilot study was to evaluate serum SSAO activity in depressed patients.
Sample Information	21 inpatients with major depression and 41 healthy controls
Method Detail	A total of 21 inpatients with major depression and 41 healthy controls were studied. Serum SSAO activity was determined by HPLC on days 1, 5 and 10 of inpatient treatment.
Method Keywords	chromatography
Result	At baseline without medication including antidepressants, highly depressed patients (MADRS score>or=30) had significantly decreased serum SSAO activity (mean 385+/-161 mU/l) when compared to healthy controls (mean 526+/-141 mU/l; p=0.003). This SSAO decrease was less pronounced at day 5 and day 10 under an antidepressive drug regime. Decreased serum SSAO activity was observed in patients with major depression, especially in those with high MADRS scores.
Conclusions	The present results support the hypothesis of dysfunctional monoaminergic metabolism in the pathogenesis of depressive disorders. The disputable association between depression and monoamine metabolism requires further investigation, particularly with regard to SSAO activity and medication status.

Relationships reported by Roessner, 2006