Study Report

Reference
Citation | Westrin, 1998 PubMed |
Full Info | Westrin, A., Ekman, R. and Traskman-Bendz, L. (1998) High delta sleep-inducing peptide-like immunoreactivity in plasma in suicidal patients with major depressive disorder. Biol Psychiatry, 43, 734-739.
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Study
Hypothesis or Background |
Delta sleep-inducing peptide (DSIP) supposedly involves the hypothalamus-pituitary-adrenal (HPA) axis. Previous studies have shown deviated plasma DSIP-like immunoreactivity (DSIP-LI) levels, as well as abnormal DSIP-LI responses to corticotropin-releasing hormone in patients with major depressive disorder (MDD). This study was performed to investigate plasma-DSIP-LI and its association with the dexamethasone suppression test (DST) in suicide attempters.
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Sample Information | 34 suicide attempters and in healthy age- and sex-matched controls |
Method Detail | Plasma-DSIP and serum cortisol were measured before and after dexamethasone intake in 34 suicide attempters and in healthy age- and sex-matched controls |
Method Keywords | blood analysis |
Result | We found significantly elevated DSIP-LI levels in MDD patients (p < .005), and a significant correlation between predexamethasone cortisol and predexamethasone DSIP-LI levels in healthy controls. Postdexamethasone DSIP-LI levels increased in subjects with low predexamethasone DSIP-LI levels, whereas they decreased in subjects with high predexamethasone DSIP-LI levels. |
Conclusions | Results give some support to the theory of glucocorticoid involvement in the regulation of DSIP, and suggest altered DSIP-LI levels in suicidal MDD patients. |

Relationships reported by
Westrin, 1998
Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
MDD
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syndrome |
TSC22 domain family protein 3 (Delta sleep-inducing peptide (DSIP)) |
protein |
P-value<0.005 |
We found significantly elevated DSIP-LI levels in MDD patients (p < .005) |
Positive
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