Study Report
Reference
Citation | Svenningsson, 2006 PubMed |
Full Info | Svenningsson, P., Chergui, K., Rachleff, I., Flajolet, M., Zhang, X., El Yacoubi, M., Vaugeois, J.M., Nomikos, G.G. and Greengard, P. (2006) Alterations in 5-HT1B receptor function by p11 in depression-like states. Science, 311, 77-80.
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Study
Hypothesis or Background |
The pathophysiology of depression remains enigmatic, although abnormalities in serotonin signaling have been implicated.
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Sample Information | an animal model of depression depressed patients |
Method Detail | transgenic method; tail suspension test |
Method Keywords | transgenic method; tail suspension test |
Result | We have found that the serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. |
Conclusions | p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant. |
Relationships reported by
Svenningsson, 2006
Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
5-hydroxytryptamine receptor 1B (serotonin 1B receptor)
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protein |
Protein S100-A10 (p11) |
protein |
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p11 increases localization of 5-HT1B receptors at the cell surface |
Positive
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Depression-like behaviors from animal model (depressive-like behavior)
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cognition and behavior |
Protein S100-A10 (p11) |
protein |
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p11 decreased in an animal model of depression and in brain tissue from depressed patients. |
Positive
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