Study Report
Reference
| Citation | Caldwell, 1991 PubMed |
| Full Info | Caldwell, C.L., Irwin, M. and Lohr, J. (1991) Reduced natural killer cell cytotoxicity in depression but not in schizophrenia. Biol Psychiatry, 30, 1131-1138.
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Study
| Hypothesis or Background |
A reduction of natural killer (NK) cell activity has been found in hospitalized patients with major depressive disorder.
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| Sample Information | hospitalized depressed patients, schizophrenic inpatients, and two groups of controls separately age matched to each patient group |
|---|
| Method Detail | To examine whether a reduction of NK activity is found in other psychiatric patients or related to the nonspecific effects of hospitalization, NK cell cytotoxicity was compared in hospitalized depressed patients, schizophrenic inpatients, and two groups of controls separately age matched to each patient group. |
| Method Keywords | |
| Result | NK activity was significantly (p less than 0.01) lower in depressed inpatients than control subjects. However, in the hospitalized schizophrenic patients values of natural cytotoxicity did not differ from controls. |
| Conclusions | These findings suggest that reduced NK cytotoxicity in depression is independent of the effects of hospitalization. |
Relationships reported by
Caldwell, 1991
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Killer Cells, Natural (natural killer (NK) cell) |
cell |
P-value-value<0.01 |
NK activity was significantly (p less than 0.01) lower in depressed inpatients than control subjects. However, in the hospitalized schizophrenic patients values of natural cytotoxicity did not differ from controls. |
Positive
|
