Study Report
Reference
| Citation | McGuffin, 2005 PubMed |
| Full Info | McGuffin, P., Knight, J., Breen, G., Brewster, S., Boyd, P.R., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L. et al. (2005) Whole genome linkage scan of recurrent depressive disorder from the depression network study. Hum Mol Genet, 14, 3337-3345.
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Study
| Hypothesis or Background |
|
| Sample Information | 497 sib pairs concordant for recurrent major depressive disorder (MDD) |
|---|
| Method Detail | Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). |
| Method Keywords | linkage analysis |
| Result | There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P < 0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined. |
Relationships reported by
McGuffin, 2005
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
13q31.1-q31.3 (13q31.1-q31.3) |
region |
P-value<0.01 |
showed evidence for linkage with a nominal P < 0.01 |
Positive
|
|
MDD
|
syndrome |
1p36 (1p36) |
region |
|
LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing) |
Positive
|
|
MDD
|
syndrome |
12q23.3-q24.11 (12q23.3-q24.11) |
region |
P-value<0.01 |
showed evidence for linkage with a nominal P < 0.01 |
Positive
|
