Study Report
Reference
| Citation | Lubar, 2003 PubMed |
| Full Info | Lubar, J.F., Congedo, M. and Askew, J.H. (2003) Low-resolution electromagnetic tomography (LORETA) of cerebral activity in chronic depressive disorder. Int J Psychophysiol, 49, 175-185.
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Study
| Hypothesis or Background |
|
| Sample Information | 15 right-handed, medication-free chronically depressed females (of the unipolar type) and age-matched non-clinical female controls |
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| Method Detail | In this study we compared the current density power and power asymmetry in 15 right-handed, medication-free chronically depressed females (of the unipolar type) and age-matched non-clinical female controls. We used frequency domain LORETA (Low-Resolution Electromagnetic Tomography). |
| Method Keywords | electroencephalogram (EEG) |
| Result | In the interhemispheric asymmetry analysis, compared with the control group, the depression group exhibited a left-to-right Alpha2 (10-12 Hz) current density dominance in the left postcentral gyrus. The pattern of left-to-right dominance included frontal (especially medial and middle frontal gyri) and temporal locations. The between groups comparison of spectral power revealed decreased activity in the right middle temporal gyrus in the depressed group. The decrease emerged in the whole frequency spectrum analyzed (2-32 Hz), although it reached significance in the Delta (2-3.5 Hz) band only. |
| Conclusions | These findings are discussed in terms of the existing literature on affect using EEG, PET and SPECT. |
Relationships reported by
Lubar, 2003
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
left postcentral gyrus (left postcentral gyrus) |
brain morphology and function |
|
In the interhemispheric asymmetry analysis, compared with the control group, the depression group exhibited a left-to-right Alpha2 (10-12 Hz) current density dominance in the left postcentral gyrus. |
Positive
|
|
MDD
|
syndrome |
right middle temporal gyrus (right middle temporal gyrus) |
brain morphology and function |
|
The between groups comparison of spectral power revealed decreased activity in the right middle temporal gyrus in the depressed group. |
Positive
|
|
MDD
|
syndrome |
Alpha wave (Alpha2 (10-12 Hz) current density) |
neurobiological system |
|
In the interhemispheric asymmetry analysis, compared with the control group, the depression group exhibited a left-to-right Alpha2 (10-12 Hz) current density dominance in the left postcentral gyrus. |
Positive
|
|
MDD
|
syndrome |
Delta wave (Delta (2-3.5 Hz)) |
neurobiological system |
|
The between groups comparison of spectral power revealed decreased activity in the right middle temporal gyrus in the depressed group. The decrease emerged in the whole frequency spectrum analyzed (2-32 Hz), although it reached significance in the Delta (2-3.5 Hz) band only. |
Positive
|
