Study Report
Reference
| Citation | Hines LM, 2006 PubMed |
| Full Info | Hines LM, Hoffman PL, Bhave S, Saba L, Kaiser A, Snell L et al. A sex-specific role of type VII adenylyl cyclase in depression. The Journal of neuroscience : the official journal of the Society for Neuroscience 2006; 26(48): 12609-12619.
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Study
| Hypothesis or Background |
Major depression represents a complex mental disorder. The identification of biological markers that define subtypes of major depressive disorder would greatly facilitate appropriate medical treatments, as well as provide insight into etiology. Reduced activity of the cAMP signaling system has been implicated in the etiology of major depression. Previous work has shown low adenylyl cyclase activity in platelets and postmortem brain tissue of depressed individuals.
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| Sample Information | individuals with no previous history of DSM-IV major depressive disorder (n=321) were 22.9% for individuals who met the DSM-IV criteria for diagnosis of major depressive disorder sometime during their lifetime (n=151) |
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| Method Detail | Here, we investigate the role of the brain type VII isoform of adenylyl cyclase (AC7) in the manifestation of depressive symptoms in genetically modified animals, using a combination of in vivo behavioral experiments, gene expression profiling, and bioinformatics. We also completed studies with humans on the association of polymorphisms in the AC7 gene with major depressive illness (unipolar depression) based on Diagnostic and Statistical Manual of Mental Disorders IV criteria. |
| Method Keywords | transgenic method; forced swimming test; tail suspension test; Q-PCR; genotyping |
| Result | |
| Conclusions | Collectively, our results demonstrate a sex-specific influence of the AC7 gene on a heritable form of depressive illness. |
Relationships reported by
Hines LM, 2006
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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Depression-like behaviors from animal model (depressive-like behavior)
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cognition and behavior |
ADCY7 (AC7) |
gene |
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Genetic manipulation of AC7 influences depression-like behavior in mice |
Positive
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MDD
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syndrome |
ADCY7 (AC7) |
gene |
allele: OR=1.28, 95%CI=0.82¨C2.01; P-value=0.28 |
We observed an increased risk formajor depression among females with the (AACA)7 allele compared with all other alleles; however, this did not reach statistical significance (adjusted OR of 1.28 per (AACA)7 allele; 95%CI of 0.82¨C2.01; p 0.28). |
Negative
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