Study Report
Reference
| Citation | Arias B, 2001 PubMed |
| Full Info | Arias B, Collier DA, Gasto C, Pintor L, Gutierrez B, Valles V et al. Genetic variation in the 5-HT5A receptor gene in patients with bipolar disorder and major depression. Neuroscience letters 2001; 303(2): 111-114
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Study
| Hypothesis or Background |
In the present study, genetic variation of the 5-HT5A receptor was analyzed in patients affected by affective disorders and healthy controls.
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| Sample Information | 181 patients with major depression, 88 patients with bipolar affective disorder (BP) and 157 unrelated controls (C), all of Spanish origin |
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| Method Detail | The sample consisted of 181 patients with major depression, 88 patients with bipolar affective disorder (BP) and 157 unrelated controls (C), all of Spanish origin. Two polymorphisms (-19G/C and 12A/T) in the 5-HT5A receptor gene were analyzed by polymerase chain reaction amplification and subsequent enzyme digestion |
| Method Keywords | genotyping |
| Result | No genotype, allele or haplotype differences were found when we compared patients and controls. When clinical variables were considered as possible tools for detecting genetic heterogeneity, no differences were found. |
| Conclusions | Our results suggest that the polymorphisms analyzed in the 5-HT5A receptor gene do not play a major role in the pathogenesis of affective disorders. |
Relationships reported by
Arias B, 2001
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
|
syndrome |
HTR5A (5-HT5A) |
gene |
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No genotype, allele or haplotype differences were found when we compared patients and controls. |
Negative
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