Study Report
Reference
| Citation | Pae CU, 2006 PubMed |
| Full Info | Pae CU, Yoon SJ, Patkar A, Kim JJ, Jun TY, Lee C et al. Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism and mood disorders: a preliminary study. Progress in neuro-psychopharmacology & biological psychiatry 2006; 30(7): 1326-1329.Pae CU, Yoon SJ, Patkar A, Kim JJ, Jun TY, Lee C et al. Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism and mood disorders: a preliminary study. Progress in neuro-psychopharmacology & biological psychiatry 2006; 30(7): 1326-1329.
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Study
| Hypothesis or Background |
This study examined the relationship between a MnSOD gene (MnSOD) polymorphism (Ala-9Val) and mood disorders such as major depressive disorder (MDD) and bipolar I disorder (BD).
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| Sample Information | Eighty patients with BD, 61 patients with MDD and 106 healthy controls |
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| Method Detail | Eighty patients with BD, 61 patients with MDD and 106 healthy controls were enrolled in this study and genotyped using a polymerase chain reaction-based method. The patients with MDD and BD, and the controls had a similar distribution of the genotypes and alleles in the Ala-9Val MnSOD polymorphism. |
| Method Keywords | genotyping |
| Result | The combined analysis (MDD plus BD) also failed to find any association between the Ala-9Val MnSOD polymorphism and mood disorders. Subgroup analyses according to the clinical variables such as the family history, age at onset, psychotic features and suicide history failed to identify any association with the Ala-9Val MnSOD polymorphism. |
| Conclusions | This preliminary data suggests that at least in the Korean population, the Ala-9Val MnSOD polymorphism is not associated with the development of mood disorders or their clinical parameters. However, more study with a larger population sample will be needed. |
Relationships reported by
Pae CU, 2006
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
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syndrome |
SOD2 (MnSOD) |
gene |
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The combined analysis (MDD plus BD) also failed to find any association between the Ala-9Val MnSOD polymorphism and mood disorders. Subgroup analyses according to the clinical variables such as the family history, age at onset, psychotic features and suicide history failed to identify any association with the Ala-9Val MnSOD polymorphism. |
Negative
|
