Study Report
Reference
| Citation | Wang, 2010 PubMed |
| Full Info | Wang, T., Zeng, Z., Li, T., Liu, J., Li, J., Li, Y., Zhao, Q., Wei, Z., Wang, Y., Li, B. et al. (2010) Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population. PLoS ONE, 5, e13662.
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Study
| Hypothesis or Background |
Myelin transcription factor 1-like (MYT1L) is a member of the myelin transcription factor 1 (MYT1) gene family, and the neural specific, zinc-finger-containing, DNA-binding protein that it encodes plays a role in the development of the nervous system. On the basis of a recent copy number variation (CNV) study showing that this gene is disrupted in mental disorder patients, we investigated whether MYT1L also plays a role in MDD.
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| Sample Information | 1139 MDD patients and 1140 controls of Chinese Han origin |
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| Method Detail | In this study, 8 SNPs were analyzed in 1139 MDD patients and 1140 controls of Chinese Han origin. |
| Method Keywords | genotyping |
| Result | Statistically significant differences were noted between cases and controls for rs3748989 (allele: permutated p = 0.0079, corrected p = 0.0048, genotype: corrected p = 0.0204). A haplotype of rs1617213 and rs6759709 G-C was also significant (permutated p = 0.00007). |
| Conclusions | Our results indicate that MYT1L may be a potential risk gene for MDD in the Chinese Han population. |
Relationships reported by
Wang, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
rs3748989 (rs3748989) |
SNP |
P-value = 0.0204 |
Statistically significant differences were noted between cases and controls for rs3748989 (allele: permutated p = 0.0079, corrected p = 0.0048, genotype: corrected p = 0.0204) |
Positive
|
|
MDD
|
syndrome |
MYT1L (MYT1L) |
gene |
P-value = 0.00007 |
A haplotype of rs1617213 and rs6759709 G-C was significant (permutated p = 0.00007) different between cases and controls |
Positive
|
|
MDD
|
syndrome |
MYT1L (Myelin transcription factor 1-like (MYT1L)) |
gene |
|
Statistically significant differences were noted between cases and controls for rs3748989 in this gene |
Negative
|
