Reactome Pathway Report
Basic Information
| ID |
|
| Name |
viral mrna_translation
|
| Description |
Spliced and unspliced viral mRNA in the cytoplasm are translated by host cell ribosomal translation machinery. At least ten viral proteins are synthesized: HA, NA, PB1, PB2, PA, NP, NS1, NEP/NS2, M1, and M2. Viral mRNA translation is believed to be enhanced by conserved 5'UTR sequences that interact with the ribosomal machinery and at least one cellular RNA-binding protein, G-rich sequence factor 1. The viral NS1 protein and the cellular protein P58. The viral NS1 protein has also been proposed to specifically enhance translation through interaction with host poly. Simultaneously, host cell protein synthesis is downregulated in influenza virus infection through still uncharacterized mechanisms. In most human influenza A strains.
|
REACT_9491 related genes in MK4MDD (count: 1)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| RPS21 |
ribosomal protein S21 |
Literature-origin
|
1(1/0) |
