Reactome Pathway Report
Basic Information
| ID |
|
| Name |
gtp hydrolysis_and_joining_of_the_60s_ribosomal_subunit
|
| Description |
Hydrolysis of eIF2-GTP occurs after the Met-tRNAi has recognized the AUG. This reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow joining of the large 60S ribosomal subunit. The 60S subunit joins - a reaction catalyzed by eIF5 or eIF5B - resulting in a translation-competent 80S ribosome. Following 60S subunit joining, eIF5B hydrolyzes its GTP and is released from the 80S ribosome, which is now ready to start elongating the polypeptide chain.
|
REACT_2085 related genes in MK4MDD (count: 2)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| RPS21 |
ribosomal protein S21 |
Literature-origin
|
1(1/0) |
| EIF4B |
eukaryotic translation initiation factor 4B |
Protein mapped
|
0(0/0) |
