Cell Report

Name	pyramidal neuron
Description	Projection neurons in the cerebral cortex and the hippocampus. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region.
No. of Studies (Positive/Negative)	6(6/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
pyramidal neurons	Stockmeier, 2004	patients and normal controls		The density of granule cells and glia in the dentate gyrus a...... The density of granule cells and glia in the dentate gyrus and pyramidal neurons and glia in all cornv ammonis (CA)/hippocampal subfields is significantly increased by 30%-35% in MDD. The average soma size of pyramidal neurons is significantly decreased in MDD More...
pyramidal	Miguel-Hidalgo, 2005	patients and normal controls		The packing density and somal size of NF200-immunoreactive (...... The packing density and somal size of NF200-immunoreactive (IR) pyramidal neurons were measured in area 9 in 13 subjects with nonpsychotic MDD, More...
pyramidal	Rajkowska, 2005	patients and normal controls		The overall (layers I-VI) packing density of ORB neurons wit...... The overall (layers I-VI) packing density of ORB neurons with pyramidal morphology was markedly decreased in MDD (by 30%) as compared with control subjects. More...
pyramidal cell	Iritani, 2006	animal model		The results showed more VMAT2-immunoreactive varicose fibers...... The results showed more VMAT2-immunoreactive varicose fibers in the pyramidal cell layer of hippocampus and parahippocampal cortexes, and more intense 5HTT-immunoreactivity in the pyramidal cell layer and the area CA4 of hippocampus in the animal models of depression compared to those of the controls. On the other hand, lower density of 5HT1a-immunoreactive deposits in the pyramidal cell layer of hippocampus and the parahippocampal cortex was observed in the animal models of depression compared to those of the controls. More...
pyramidal neuronal	Khundakar, 2009	patients and normal controls		We found a decrease in pyramidal neuronal size in the dorsol...... We found a decrease in pyramidal neuronal size in the dorsolateral prefrontal cortex in late-life depression. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
pyramidal neurons		Flutamide(flutamide)	molecule	Zhang, 2010	animal model		Compared to vehicle controls, flutamide treatment significan...... Compared to vehicle controls, flutamide treatment significantly decreased the density of dendritic spines of pyramidal neurons in the CA1 region. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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