Epigenetic Site Report

Epigenetic Site Name	methylation-BDNF-22901293
Related Gene	BDNF
Location	chr11:0-0
Distance to Transcriptional Start Site(bp)	0
Relation to Gene	promoter
No. of Studies (Positive/Negative)	1 (1/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
methylation-BDNF-22901293	D'Addario C, 2013	patients and normal controls	P-value <0.05	A signi?cant reduction of BDNF gene expression in MDD subjec...... A signi?cant reduction of BDNF gene expression in MDD subjects (.45+/-.10; p<.05, according to unpaired t test) versus controls(1.00+/-.21; Figure 1A)was observed. In addition, an increase of DNA methylation at BDNF gene promoter was observed in MDD patients, compared with control subjects (32.52% +/- 2.03% vs.24.04%+/- 2.08%; p <.05, according to unpaired t test; Figure 1B) More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web