MK4MDD

Environment Report

Basic Information
Name Social isolation
Description "Social isolation refers to a lack of contact with members of one's species. In humans, it may be caused by a pervasive withdrawal or avoidance of social contact or communication.Research by Cole and colleagues showed that perceived social isolation is associated with gene expression-specifically, the under-expression of genes bearing anti-inflammatory glucocorticoid response elements and over-expression of genes bearing response elements for pro-inflammatory NK-K B/Rel transcription factors. This finding is paralleled by decreased lymphocyte sensitivity to physiological regulation by the hypothalamic pituitary adrenocortical (HPA) axis in lonely individuals, which together with evidence of increased activity of the HPA axis, suggests the development of glucocorticoid resistance in chronically lonely individuals. "
No. of Studies (Positive/Negative) 1(1/0) Help

Positive relationships between Social isolation and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
social isolation Chou, 2011 nomal people P-value < .01 We found that the absence of close friends was associated (P...... We found that the absence of close friends was associated (P < .01) with an increased risk of major depressive disorder More...

Positive relationships between Social isolation and other components at different levels (count: 0) Help
Positive relationship network of Social isolation in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Social isolation and MDD (count: 0)
Negative relationships between Social isolation and other components at different levels (count: 0) Help