Neurobiological Component Report

Name	Slow wave potential
Description	In physiology, a slow wave potential is a membrane potential that cycles between depolarizations and repolarizations. Slow wave potentials are generated by myocytes. Due to temporal summation, a slow wave potential will periodically reach threshold and generate an action potential. This in turn triggers contraction of a myocyte. Since each cycle of a slow wave potential does not always reach threshold, an action potential (AP) does not always fire as a result. Slow waves are intrinsic: they do not rely on exogenous stimulus, but they can be altered by an exogenous stimulus. Slow cortical potential studies have shown that the post-imperative negative variation (PINV) is a suitable indicator of information processing during uncontrollability over aversive events.
No. of Studies (Positive/Negative)	2 (2/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
temporal slow waves	Motomura, 2002	patients and normal controls	in depressed patients (47%)	Temporal slow waves were more common in depressed patients (...... Temporal slow waves were more common in depressed patients (47%) than in normal controls (22%). More...
post-imperative negative variation (PINV)	Diener, 2009	patients and normal controls		Depressed participants showed an enhanced frontal PINV as an...... Depressed participants showed an enhanced frontal PINV as an electrophysiological index of altered information processing during both loss of control and restitution of control. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
temporal slow waves		Feelings of hopelessness, worthlessness, and guilt(feeling of guilt)	symptoms	Motomura, 2002	patients and normal controls	P-value <0.01	each score of HAMD in patients with temporal slow waves show...... each score of HAMD in patients with temporal slow waves showed a significantly lower score for feeling of guilt (P<0.01) More...
temporal slow waves		Somatic symptoms(general somatic symptoms)	symptoms	Motomura, 2002	patients and normal controls	P-value <0.01	each score of HAMD in patients with temporal slow waves show...... each score of HAMD in patients with temporal slow waves showed a significantly higher score for general somatic symptoms (P<0.01) More...
temporal slow waves		Neuroticism(hypochondriasis)	symptoms	Motomura, 2002	patients and normal controls	P-value <0.01	each score of HAMD in patients with temporal slow waves show...... each score of HAMD in patients with temporal slow waves showed a significantly higher score for hypochondriasis (P<0.01). More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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