Neurobiological Component Report

Name	Sleep spindle activity (SPA)
Description	Sleep spindles (sometimes referred to as "sigma bands" or "sigma waves") may represent periods where the brain is inhibiting processing to keep the sleeper in a tranquil state. Along with K-complexes they are defining characteristics of, and indicate the onset of, stage 2 sleep. They are often tapered at both ends and frequently seen over the frontal and central head regions. They may or may not be synchronous, but they should be symmetrical and bilateral. During sleep these spindles are seen in the brain as a burst of activity immediately following muscle twitching. Researchers think the brain, particularly in the young, is learning about what nerves control what specific muscles when asleep.
Picture	Source
No. of Studies (Positive/Negative)	1 (1/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
sleep spindle activity (SPA)	Lopez, 2010	patients and normal controls	P-value = 0.0004	Both the MDD (p = .0004) and at high-risk groups (p = .02) h...... Both the MDD (p = .0004) and at high-risk groups (p = .02) had significantly lower SPA compared with healthy controls. More...

---

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web