Brain Morphology and Function Report

Name	Septal area
Brain Morphology	The septal area (medial olfactory area) are structures that lie below the rostrum of corpus callosum in front of lamina terminalis (the layer of gray matter in the brain connecting the optic chiasma and the anterior commissure where the latter becomes continuous with the rostral lamina), composed of medium-size neurons grouped into medial, lateral, and posterior groups. The septal nuclei receive reciprocal connections from the olfactory bulb, hippocampus, amygdala, hypothalamus, midbrain, habenula, cingulate gyrus, and thalamus.
Brain Function	The septal area (medial olfactory area) has no relation to the smell, but it is considered a pleasure zone in animals. The septal nuclei play a role in reward and reinforcement along with the nucleus accumbens. In the 1950s, Olds & Milner showed that rats with electrodes implanted in this area will self-stimulate repeatedly in order to experience a euphoric feeling (i.e. press a bar to receive electrical current that will stimulate the neurons).
No. of Studies (Positive/Negative)	1(1/0)

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
septal region		Serotonergic system(serotonergic (5-HT) system)	neurobiological system	Morris, 1999	patients only		Neural activity in several 5-HT-related brain areas, e.g., d...... Neural activity in several 5-HT-related brain areas, e.g., dorsal raphe, habenula, septal region, amygdala, and orbitofrontal cortex, covaried significantly with plasma levels of tryptophan and ratings of depressed mood. More...
septal region		Depressed mood(depressed mood)	symptoms	Morris, 1999	patients only		Neural activity in several 5-HT-related brain areas, e.g., d...... Neural activity in several 5-HT-related brain areas, e.g., dorsal raphe, habenula, septal region, amygdala, and orbitofrontal cortex, covaried significantly with ratings of depressed mood. More...

---

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web