Gene Report

Basic Information

Approved Symbol	SWAP70
Approved Name	SWAP switching B-cell complex 70kDa subunit
Symbol Alias	KIAA0640, SWAP-70
Location	11p15
Position	chr11:9771518-9774508 (+)
External Links	Entrez Gene: 23075 Ensembl: ENSG00000133789 UCSC: uc001mhw.3 HGNC ID: 17070
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SWAP70 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
KIAA0640 protein	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between SWAP70 and other components at different levels (count: 0)

Positive relationship network of SWAP70 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SWAP70 and MDD (count: 0)

Negative relationships between SWAP70 and other components at different levels (count: 0)

SWAP70 related SNPs in MK4MDD (count: 0)

SWAP70 related proteins in MK4MDD (count: 0)

SWAP70 related GO terms (count: 20)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0005856	cytoskeleton	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0060754	positive regulation of mast cell chemotaxis	biological process	IEA
GO:0003677	DNA binding	molecular function	IEA
GO:0051017	actin filament bundle assembly	biological process	IEA
GO:0030835	negative regulation of actin filament depolymerization	biological process	IEA
GO:0005509	calcium ion binding	molecular function	IEA
GO:0033633	negative regulation of cell-cell adhesion mediated by integrin	biological process	IEA
GO:0030027	lamellipodium	cellular component	IEA
GO:0005524	ATP binding	molecular function	IEA
GO:0032880	regulation of protein localization	biological process	IEA
GO:0005829	cytosol	cellular component	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0005515	protein binding	molecular function	IPI[25416956]
GO:0045190	isotype switching	biological process	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0005886	plasma membrane	cellular component	IEA
GO:0032233	positive regulation of actin filament bundle assembly	biological process	IEA
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IEA
GO:0005634	nucleus	cellular component	IEA
GO:1902309	negative regulation of peptidyl-serine dephosphorylation	biological process	IEA

SWAP70 related KEGG pathways (count: 0)

SWAP70 related BioCarta pathways (count: 0)

SWAP70 related Reactome pathways (count: 0)

SWAP70 related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SWAP70	PARP1	No	in vitro	9642267
SWAP70	IGHG1	No	in vitro	10681448
SWAP70	CELSR3	No	yeast 2-hybrid	12421765

Gene Report

Literature-origin GO terms

Gene mapped GO terms