Gene Report

Basic Information

Approved Symbol	STAG2
Approved Name	stromal antigen 2
Symbol Alias	SA-2, SCC3B
Location	Xq25
Position	chrX:123234448-123236349 (+)
External Links	Entrez Gene: 10735 Ensembl: ENSG00000101972 UCSC: uc004eua.3 HGNC ID: 11355
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between STAG2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
STAG2	Chu TT, 2009	Patients and nomal controls		Down regulation, fold change([MD] vs [C]) 2.1440032 Down regulation, fold change([MD] vs [C]) 2.1440032

Positive relationships between STAG2 and other components at different levels (count: 0)

Positive relationship network of STAG2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between STAG2 and MDD (count: 0)

Negative relationships between STAG2 and other components at different levels (count: 0)

STAG2 related SNPs in MK4MDD (count: 0)

STAG2 related proteins in MK4MDD (count: 0)

STAG2 related GO terms (count: 26)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0003682	chromatin binding	molecular function	IEA
GO:0005694	chromosome	cellular component	TAS
GO:0051301	cell division	biological process	IEA
GO:0032876	negative regulation of DNA endoreduplication	biological process	IMP[15917200]
GO:0016020	membrane	cellular component	IDA[19946888]
GO:0019827	stem cell population maintenance	biological process	IEA
GO:0016925	protein sumoylation	biological process	TAS
GO:0005886	plasma membrane	cellular component	IDA
GO:0043687	post-translational protein modification	biological process	TAS
GO:0005634	nucleus	cellular component	IDA; TAS[9305759]
GO:0005730	nucleolus	cellular component	IDA
GO:0006366	transcription from RNA polymerase II promoter	biological process	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA
GO:0007067	mitotic nuclear division	biological process	IEA
GO:0000278	mitotic cell cycle	biological process	TAS
GO:0044267	cellular protein metabolic process	biological process	TAS
GO:0015629	actin cytoskeleton	cellular component	IDA
GO:0005654	nucleoplasm	cellular component	TAS
GO:0005829	cytosol	cellular component	TAS
GO:0051321	meiotic cell cycle	biological process	IEA
GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	molecular function	IEA
GO:0000775	chromosome, centromeric region	cellular component	TAS
GO:0000785	chromatin	cellular component	IDA[16682347]
GO:0007062	sister chromatid cohesion	biological process	IMP[15917200]
GO:0005515	protein binding	molecular function	IPI[15855230\|16682347\|17113138\|17349791\|17962804\|19629043\|20818333\|26496610]
GO:0045111	intermediate filament cytoskeleton	cellular component	IDA

STAG2 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04110	cell cycle	Cell cycle	Mitotic cell cycle progression is accomplished through a rep...... Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation. More...

STAG2 related BioCarta pathways (count: 0)

STAG2 related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_21300	mitotic m_m_g1_phases
REACT_682	mitotic prometaphase	The dissolution of the nuclear membrane marks the beginning ...... The dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and the chromosomes begin to move. More...
REACT_152	cell cycle_mitotic	The replication of the genome and the subsequent segregation...... The replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried out during a discrete temporal period known as the S (synthesis)-phase, and chromosome segregation occurs during a massive reorganization to cellular architecture at mitosis. Two gap-phases separate these major cell cycle events: G1 between mitosis and S-phase, and G2 between S-phase and mitosis. In the development of the human body, cells can exit the cell cycle for a period and enter a quiescent state known as G0, or terminally differentiate into cells that will not divide again, but undergo morphological development to carry out the wide variety of specialized functions of individual tissues. A family of protein serine/threonine kinases known as the cyclin-dependent kinases (CDKs) controls progression through the cell cycle. As the name suggests, the activity of the catalytic subunit is dependent on binding to a cyclin partner. The human genome encodes several cyclins and several CDKs, with their names largely derived from the order in which they were identified. The oscillation of cyclin abundance is one important mechanism by which these enzymes phosphorylate key substrates to promote events at the relevant time and place. Additional regulatory proteins and post-translational modifications ensure that CDK activity is precisely regulated, frequently confined to a narrow window of activity. More...

STAG2 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
STAG2	STAG1	No	in vitro;in vivo	11076961
STAG2	RAD21	No	in vivo	11590136 , 12034751

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways