Gene Report

Basic Information

Approved Symbol	SP4
Approved Name	Sp4 transcription factor
Symbol Alias	SPR-1, HF1B, MGC130008, MGC130009
Location	7p15
Position	chr7:21550888-21554162 (+)
External Links	Entrez Gene: 6671 Ensembl: ENSG00000105866 UCSC: uc003sva.3 HGNC ID: 11209
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SP4 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SP4	Jansen R, 2015	patients and normal controls	P-value=0.000164;FDR=0.0918;beta=-0.242	we found 129 genes (142 probesets) differentially expressed ...... we found 129 genes (142 probesets) differentially expressed between the control and current MDD groups (FDR<0.1) More...

Positive relationships between SP4 and other components at different levels (count: 0)

Positive relationship network of SP4 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SP4 and MDD (count: 0)

Negative relationships between SP4 and other components at different levels (count: 0)

SP4 related SNPs in MK4MDD (count: 0)

SP4 related proteins in MK4MDD (count: 0)

SP4 related GO terms (count: 13)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005634	nucleus	cellular component	IBA
GO:0005737	cytoplasm	cellular component	IDA
GO:0015630	microtubule cytoskeleton	cellular component	IDA
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	IDA[12560508]
GO:0046872	metal ion binding	molecular function	IEA
GO:0006351	transcription, DNA-templated	biological process	IEA
GO:0003713	transcription coactivator activity	molecular function	IEA
GO:0005654	nucleoplasm	cellular component	IDA
GO:0005515	protein binding	molecular function	IPI[25416956]
GO:0045171	intercellular bridge	cellular component	IDA
GO:0003677	DNA binding	molecular function	IEA
GO:0008016	regulation of heart contraction	biological process	IEA
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	molecular function	IBA

SP4 related KEGG pathways (count: 0)

SP4 related BioCarta pathways (count: 0)

SP4 related Reactome pathways (count: 0)

SP4 related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SP4	ZBTB7A	No	in vitro	12004059
SP4	E2F1	No	in vitro;in vivo	10547281
SP4	SP1	No	in vitro	7559627

Gene Report

Gene mapped GO terms