Gene Report

Basic Information

Approved Symbol	SIRT2
Approved Name	sirtuin 2
Previous Symbol	SIR2L
Previous Name	sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2, "sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)"
Location	19q13
Position	chr19:39369195-39390502 (-)
External Links	Entrez Gene: 22933 Ensembl: ENSG00000068903 UCSC: uc002ojt.2 HGNC ID: 10886
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SIRT2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
sirtuin	Abe, 2011	patients and normal controls		The SIRT1, 2 and 6 mRNA levels in MDD patients decreased sig...... The SIRT1, 2 and 6 mRNA levels in MDD patients decreased significantly in those who were in a depressive state compared to healthy controls More...

Positive relationships between SIRT2 and other components at different levels (count: 0)

Positive relationship network of SIRT2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SIRT2 and MDD (count: 0)

Negative relationships between SIRT2 and other components at different levels (count: 0)

SIRT2 related SNPs in MK4MDD (count: 0)

SIRT2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	0(0/0)	Gene mapped

SIRT2 related GO terms (count: 29)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0051775	response to redox state	biological process	NAS[12887892]
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	biological process	IMP
GO:0000183	chromatin silencing at rDNA	biological process	NAS[11427894]
GO:0007067	mitosis	biological process	IEA
GO:0008134	transcription factor binding	molecular function	IPI[15126506]
GO:0043130	ubiquitin binding	molecular function	IDA[12697818]
GO:0008270	zinc ion binding	molecular function	IDA[11427894]
GO:0007096	regulation of exit from mitosis	biological process	NAS[12697818]
GO:0045843	negative regulation of striated muscle tissue development	biological process	IDA[12887892]
GO:0042325	regulation of phosphorylation	biological process	NAS[12697818]
GO:0005515	protein binding	molecular function	IPI
GO:0016575	histone deacetylation	biological process	TAS[12697818]
GO:0005737	cytoplasm	cellular component	IDA[16079181]
GO:0005677	chromatin silencing complex	cellular component	NAS[12697818]
GO:0016458	gene silencing	biological process	NAS[10381378]
GO:0003950	NAD+ ADP-ribosyltransferase activity	molecular function	TAS[17456799]
GO:0006348	chromatin silencing at telomere	biological process	NAS[11427894]
GO:0005874	microtubule	cellular component	IDA[12620231]
GO:0033558	protein deacetylase activity	molecular function	IDA[17172643]
GO:0006471	protein ADP-ribosylation	biological process	NAS[10381378]; TAS[17456799]
GO:0006476	protein deacetylation	biological process	IDA[17172643]
GO:0042826	histone deacetylase binding	molecular function	IPI[12620231]
GO:0042903	tubulin deacetylase activity	molecular function	IDA[12620231]
GO:0045892	negative regulation of transcription, DNA-dependent	biological process	IDA[12887892]
GO:0017136	NAD-dependent histone deacetylase activity	molecular function	IDA[11427894]
GO:0006342	chromatin silencing	biological process	NAS[12697818]
GO:0051301	cell division	biological process	IEA
GO:0035035	histone acetyltransferase binding	molecular function	IPI[12887892]
GO:0070403	NAD+ binding	molecular function	IDA[11427894]

SIRT2 related KEGG pathways (count: 0)

SIRT2 related BioCarta pathways (count: 0)

SIRT2 related Reactome pathways (count: 0)

SIRT2 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SIRT2	CDC14B	No	in vitro;in vivo	12697818
SIRT2	HDAC6	No	in vivo	12620231
SIRT2	HOXA10	No	in vitro;in vivo;yeast 2-hybrid	15213244
SIRT2	TUBA4A	No	in vitro;in vivo	12620231
SIRT2	KAT2A	No	in vivo	12887892
SIRT2	KAT2B	No	in vivo	12887892
SIRT2	SP140	No	in vivo	12887892

Gene Report

Gene mapped GO terms