Signs Report

Name	Retinal contrast gain
Description	To assess a possible relationship between visual contrast processing at the level of the retina and depressive phenomena, we measured the pattern electroretinogram (PERG)-based contrast gain (hereafter "contrast gain") to achromatic, gray checkerboard stimuli in healthy control subjects, unmedicated patients with MDD, and medicated patients with MDD. The PERG is an objective electrophysiologic response, recorded at the cornea in response to visual pattern stimulation. It mainly represents activity of the retinal ganglion cells and thus can serve as a surrogate marker of retinal information processing from the photoreceptors to the beginning of the optic nerve. (E. Bubl et al.,2010; PMID: 20359698)
No. of Studies (Positive/Negative)	1 (1/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
retinal contrast gain	Bubl, 2010	patients and normal controls		Unmedicated and medicated depressed patients displayed drama...... Unmedicated and medicated depressed patients displayed dramatically lower retinal contrast gain. We found a strong and significant correlation between contrast gain and severity of depression. More...

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Note:
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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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