Brain Morphology and Function Report

Name	Raphe nuclei
Brain Morphology	The raphe nuclei are a moderate-size cluster of nuclei found in the brain stem.
Brain Function	Their main function is to release serotonin to the rest of the brain. Selective serotonin reuptake inhibitor (SSRI) antidepressants are believed to act in these nuclei, as well as at their targets.
Picture	Source
No. of Studies (Positive/Negative)	3(2/1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
median raphe nucleus	Bach-Mizrachi, 2006	patients and normal controls	33% higher in the DRN and 17% higher in the MRN	TPH2 expression is 33% higher in the DRN and 17% higher in t...... TPH2 expression is 33% higher in the DRN and 17% higher in the MRN as compared to matched nonpsychiatric controls More...
dorsal raphe nuclei	Lee, 2011	patients and normal controls		Decreased gray matter concentration was found in MDD patient...... Decreased gray matter concentration was found in MDD patients in the bilateral amygdalae, hippocampi, fusiform gyri, lingual gyri, insular gyri, middle-superior temporal gyri, thalami, cingulate gyri, the central lobule of the cerebellum, and the midbrain encompassing the dorsal raphe nuclei (DRN) More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
raphe nuclei	Ordway, 2003	patients and normal controls		No significant differences were observed in p-[125I]iodoclon...... No significant differences were observed in p-[125I]iodoclonidine binding to alpha2-adrenoceptors in the raphe nuclei comparing MD and control subjects. More...