Brain Morphology and Function Report

Name	Periaqueductal gray
Brain Morphology	Periaqueductal gray (PAG) is the gray matter located around the cerebral aqueduct within the tegmentum of the midbrain.
Brain Function	It plays a role in the descending modulation of pain and in defensive behaviour. The ascending pain and temperature fibers of the spinothalamic tract also send information to the PAG via the spinomesencephalic tract (so-named because the fibers originate in the spine and terminate in the PAG, in the mesencephalon or midbrain).
No. of Studies (Positive/Negative)	2(2/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
periaqueductal gray	Cannon, 2007	patients and normal controls	PAG, 20%, 22%	The unipolar-depressives had elevated 5-HTT BP relative to b...... The unipolar-depressives had elevated 5-HTT BP relative to both BD (bipolar-depressives) and HC (healthy-controls) groups in the vicinity of the periaqueductal gray (PAG, 20%, 22%, respectively). More...
periaqueductal gray matter	Strigo, 2008	patients and normal controls		Subjects with MDD compared with healthy controls showed decr...... Subjects with MDD compared with healthy controls showed decreased activation in periaqueductal gray matter during painful stimulation relative to nonpainful stimulation, More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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