Gene Report

Basic Information

Approved Symbol	PRG3
Approved Name	proteoglycan 3
Symbol Alias	MBPH
Location	11q12.1
Position	chr11:57144242-57148623 (-)
External Links	Entrez Gene: 10394 Ensembl: ENSG00000156575 UCSC: uc001njv.2 HGNC ID: 9363
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PRG3 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PRG-3	Klempan, 2009	patients and normal controls		Selected differentially expressed genes in BA44 to BA47 (ANO...... Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t) More...

Positive relationships between PRG3 and other components at different levels (count: 0)

Positive relationship network of PRG3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PRG3 and MDD (count: 0)

Negative relationships between PRG3 and other components at different levels (count: 0)

PRG3 related SNPs in MK4MDD (count: 0)

PRG3 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Proteoglycan 3	Q9Y2Y8	0(0/0)	Gene mapped

PRG3 related GO terms (count: 9)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0045416	positive regulation of interleukin-8 biosynthetic process	biological process	IDA[10318872]
GO:0030246	carbohydrate binding	molecular function	IEA
GO:0042119	neutrophil activation	biological process	IDA[10318872]
GO:0045575	basophil activation	biological process	IDA[10318872]
GO:0042554	superoxide anion generation	biological process	IDA[10318872]
GO:0017148	negative regulation of translation	biological process	IDA[10318872]
GO:0001694	histamine biosynthetic process	biological process	IDA[10318872]
GO:0019370	leukotriene biosynthetic process	biological process	IDA[10318872]
GO:0006955	immune response	biological process	IEA

PRG3 related KEGG pathways (count: 0)

PRG3 related BioCarta pathways (count: 0)

PRG3 related Reactome pathways (count: 0)

PRG3 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms